Shape annealing, a computational design method applied to structural design, has been extended to the design of traditional and innovative three-dimensional domes that incorporate the design goals of efficiency, economy, utility, and elegance. In contrast to deterministic structural optimization methods, shape annealing, a stochastic method, uses lateral exploration to generate multiple designs...

The detection of pathological changes in neurodegenerative diseases that occur before clinical onset would be of great value for identifying suitable subjects and assessing drug e cacy in trials aimed at preventing or slowing onset. Using MRI derived volumetric information, researchers have been able to detect significant di↵erences between patients in the presymptomatic phase of neurodegenerat...