نتایج جستجو برای: Sirt1

تعداد نتایج: 4906  

ژورنال: :مجله دانشگاه علوم پزشکی فسا 0
کیارش بهروزفر kiarash behrouzfar department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.گروه بیوشیمی، دانشکده ی پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران. میترا نوربخش mitra nourbakhsh department of clinical biochemistry, school of medicine, iran university of medical sciences, tehran, iran.گروه بیوشیمی، دانشکده ی پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران محمد اعلایی mohammad alaiee department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran.گروه بیوشیمی، دانشکده ی پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران.

زمینه و هدف: سرطان پستان شایع ترین سرطان و دومین علت مرگ و میر ناشی از سرطان در میان زنان است. یکی از تغییراتی که در بیماران مبتلا به سرطان پستان مشاهده می شود، بالا رفتن ویسفاتین یا نیکوتین آمید فسفوریبوزیل ترانسفراز در بافت توموری و خون این بیماران است. میزان ویسفاتین و فعالیت (سیرتوئین 1) sirt1 در سلول­های سرطانی مختلف افزایش یافته است و میزان آن ها با پیش آگهی سرطان همبستگی دارد. هدف از مطا...

Journal: :archives of medical laboratory sciences 0
solaleh emamgholipour department of clinical biochemistry, school of medicine, tehran university of medical sciences, tehran, iran mohammad ali sahraian somayeh shapourizadeh mohammad ansari - archives of medical laboratory sciences

background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

Background:The aim of this study was to evaluate the effect of Ramadan fasting on SIRT1 mRNA expression in healthy men.Islamic Ramadan fasting is a holy religious ceremony that has many spiritual benefits. Additionally, it can be considered as the equivalent of calorie restriction that may affect physical health. The results of previous studies revealed that calorie restriction increases the li...

Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to evaluate the effect of AMPK/SIRT1 pathway on autophagy after spinal cord injury (SCI). Materials and Methods:The SCI model was established in rats in vivo and the primary spinal cord neurons were subject...

Journal: :Artery Research 2023

Abstract Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents humans. Human were limited due to availability biological material exclusively advanced stage disease. The role sirtuins pathology has not been explained extensively therefore aim study was assess plasma concentrations human 1 (SIRT1) 2 (SIRT2) patients with...

Journal: :International journal of clinical and experimental medicine 2015
Xianzhen Zhang Suiqin Chen Meili Cheng Fangli Cao Yufeng Cheng

SIRT1 is the homologue of sir2 in mammals, which is a nicotinamide adenine dinucleotide (NAD(+)) dependent histone deacetylase. SIRT1 is involved in many physiological processes, such as metabolism, senescence, inflammatory response, neuroprotection, and tumorigenesis by acetylating histones and multiple transcription factors. However, the exact role of SIRT1 in tumor is still under controversi...

Journal: :Frontiers in Marine Science 2022

Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor ? (LXR?) play important roles in regulating cholesterol metabolism mammals. However, little is known about the relationship between SIRT1, LXR?, SREBP-1 fish. In addition, knowledge of effects salinity on hepatic euryhaline teleosts fragmented. This study revealed that content was significantly different ...

alaiee, mohammad, behrouzfar, kiarash, nourbakhsh, mitra,

Background & Objectives: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Obesity, hormones, and growth factors are the risk factors for this kind of cancer. One of the changes observed in patients suffering from breast cancer is the elevated Visfatin or nicotinamide phosphoribosyl transferase (NAMPT) in their tumor tissues and blood. The increa...

Introduction. The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats.  Method. Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrifi...

2010
Cian J. Lynch Zahid H. Shah Simon J. Allison Shafiq U. Ahmed Jack Ford Lorna J. Warnock Han Li Manuel Serrano Jo Milner

BACKGROUND The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, prec...

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