The aim of this study was to develop a user-friendly model for spray drying that can aid in the development of a pharmaceutical product, by shifting from a trial-and-error towards a quality-by-design approach. To achieve this, a spray dryer model was developed in commercial and open source spreadsheet software. The output of the model was first fitted to the experimental output of a Büchi B-290...

The structural and physical stability of solid dispersions have not been adequately explored during spray drying manufacturing processes. In this study a wide range of compositions of naproxen/PVP-VA 64 (poly(1-vinylpyrrolidone-co-vinyl acetate)) and miconazole/PVP-VA 64 solid dispersions prepared by different laboratory spray dryers were collected from various selected locations and used to in...

UNLABELLED Spray-dried monoclonal antibody (mAb) powders may offer applications more versatile than the freeze-dried cake, including preparing high-concentration formulations for subcutaneous administration. Published studies on this topic, however, are generally scarce. This study evaluates a pilot-scale spray dryer against a laboratory-scale dryer to spray-dry multiple mAbs in consideration o...

Spray drying is a commonly used method of drying a liquid feed through a hot gas. This study aims to obtain the empirical model of the spray drying process of full cream milk using a nozzle atomizer spray dryer, Lab-Plant SD 05 Laboratory Scale Spray Dryer. Inlet air temperature was chosen as the manipulated variable and outlet air temperature was the controlled variable. No disturbance was con...

The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. Among attractive drugs, calpain inhibitor that inhibits programmed cell death 'apoptosis' is a candidate for curing apoptosis-mediated intractable diseases such as Alzheimer's disease and Parkinson's disease. In this study, the preparation of calpain inhibitor nanocrystals using Nan...

A study was conducted using LabPlant SD-06 Spray Dryer to produce spray-dried rosellepineapple powder. Roselle calyces and pineapples were extracted under optimum condition. Three different maltodextrin DE 10 concentrations (3%, 5% and 10%) were added (w/w) as the encapsulating agent prior to spray drying. Inlet temperatures were varied at 140 C, 160 C and 180 C respectively and the outlet temp...

The removal of CO2 through chemical absorption in a bench-scale spray dryer absorber was investigated experimentally using the lime slurry as absorbent. The effect of important operating parameters on CO2 removal efficiency has been investigated; in selected ranges of operating parameters, increasing gas inlet temperature and absorbent concentration lead to permanent efficiency decline, increas...

The Nano Spray Dryer B-90 offers a new, simple, and alternative approach for the production of drug nanocrystals. In this study, the preparation of steroid nanocrystals using the Nano Spray Dryer B-90 was demonstrated. The particle size was controlled by selecting the mesh aperture size. Submicrometer steroid particles in powder form were successfully obtained. These nanoparticles were confirme...

Multi-stage spray drying is an important and widely used unit operation in the production of food powders. In this paper we develop and present a dynamic model of the complete drying process in a multi-stage spray dryer. The dryer is divided into three stages: The spray stage and two fluid bed stages. Each stage is assumed ideally mixed and described by massand energy balances. The model is abl...