Aim: To study the effect of hydro-ethanolic extract Flueggea virosa on Streptozotocin-induced hyperglycemia in rats with respect to kidney function parameters and histology.
 Methods: 
 Daily single oral doses (100 200 mg/kg) anti-diabetic drug Metformin (500 were administered for 21 days three groups rendered diabetic by a injection Streptozotocin (60mg/kg). The body weight blood glu...

Abstract: Aim: This study aimed to establish the dose of streptozotocin required induce Type -1 diabetes in Wistar rats. Background: Streptozotocin is currently employed worldwide insulin-dependent mellitus also known as 1 experimental animals. Though many reports on use induction are reported literature, they were not reproducible. Moreover, there was no mention mortality associated with same ...

Background: Chronic hyperglycemia is associated with long-term damage in the structure and functions of female gonads, especially ovaries uterus. Inulin major component Chicory (Cichorium intybus L.) roots leaves. used to prepare appropriate low caloric foods for diabetic patients maintain blood sugar levels. Aim: This work was mainly designed evaluate ameliorative role inulin extract on metabo...

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

To study the effect of diabetes on hepatic protein synthesis and polysomal aggregation in pregnant rats, female rats were treated with streptozotocin prior to conception. Some animals were mated, and studied at day 20 of pregnancy, whereas, others were studied in parallel under non pregnant conditions. The protein synthesis rate measured with an "in vitro" cell-free system was higher in pregnan...

Constant infusion of [14C]tyrosine has been used to measure the fractional rates of protein synthesis in viuo in skeletal muscle, heart and liver of normal, streptozotocin diabetic and insulin-treated rats. Diabetes resulted in a 70% reduction in the rate of protein synthesis in skeletal muscle, and a 44 % reduction in that in heart. Insulin treatment increased the protein synthesis rate in bot...

The effect of halothane anaesthesia on the activity of the mitochondrial enzyme pyruvate dehydrogenase was studied in starved lactating rats. Extracts of freeze-clamped mammary gland and liver were assayed for pyruvate dehydrogenase activity. The fraction of the enzyme in the phosphorylated inactive form was increased greatly by starvation or by streptozotocin diabetes, and halothane anaesthesi...

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...

Oxidative stress is involved in both the pathogenesis and complications of diabetes. ACE inhibitors can slow the progression of cardiac and renal impairments related to diabetes. The effect of enalapril treatment on oxidative stress and tissue injury was studied in hearts, kidneys, and livers from streptozotocin-induced diabetic rats. Twenty-four rats were divided into the following groups: str...

Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. The aim of the study was to investigate the effects of trigonelline on experimental diabetes-induced disorders in the rat skeletal system. Effects of trigonelline (50 mg/kg p.o. daily for four weeks) were investigated in three-month-old female Wist...