نتایج جستجو برای: streptozotocin

تعداد نتایج: 12071  

Journal: :Journal of Pharmaceutical Negative Results 2022

Aim: To study the effect of hydro-ethanolic extract Flueggea virosa on Streptozotocin-induced hyperglycemia in rats with respect to kidney function parameters and histology.
 Methods: 
 Daily single oral doses (100 200 mg/kg) anti-diabetic drug Metformin (500 were administered for 21 days three groups rendered diabetic by a injection Streptozotocin (60mg/kg). The body weight blood glu...

Journal: :Indian Journal of Pharmaceutical Education and Research 2023

Abstract: Aim: This study aimed to establish the dose of streptozotocin required induce Type -1 diabetes in Wistar rats. Background: Streptozotocin is currently employed worldwide insulin-dependent mellitus also known as 1 experimental animals. Though many reports on use induction are reported literature, they were not reproducible. Moreover, there was no mention mortality associated with same ...

Journal: :The Egyptian Journal of Histology 2021

Background: Chronic hyperglycemia is associated with long-term damage in the structure and functions of female gonads, especially ovaries uterus. Inulin major component Chicory (Cichorium intybus L.) roots leaves. used to prepare appropriate low caloric foods for diabetic patients maintain blood sugar levels. Aim: This work was mainly designed evaluate ameliorative role inulin extract on metabo...

Journal: :فصلنامه علمی پژوهشی گیاهان دارویی 0
a khaki no. 1 ettekali la, south shariati street, 5138815941, tabriz, iran, mobile phone: +98-9143138-399 m nouri department of biochemistry, tabriz university of medical sciences, iran f fathiazad department of pharmacognosy tabriz university of medical sciences, iran hr ahmadi-ashtiani clinical biochemistry, tarbiat-e-modarres university, school of medical science, department of clinical biochemistry, tehran, iran and biochemistry & nutrition department of zanjan medical university h rastgar ministry of health and medical education, food & drug laboratory research center, tehran, iran sh rezazadeh department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr, tehran, iran

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

Journal: :Bioscience reports 1995
M E Martin A M Garcia L Blanco E Herrera M Salinas

To study the effect of diabetes on hepatic protein synthesis and polysomal aggregation in pregnant rats, female rats were treated with streptozotocin prior to conception. Some animals were mated, and studied at day 20 of pregnancy, whereas, others were studied in parallel under non pregnant conditions. The protein synthesis rate measured with an "in vitro" cell-free system was higher in pregnan...

Journal: :The Journal of biological chemistry 1974
V M Pain P J Garlick

Constant infusion of [14C]tyrosine has been used to measure the fractional rates of protein synthesis in viuo in skeletal muscle, heart and liver of normal, streptozotocin diabetic and insulin-treated rats. Diabetes resulted in a 70% reduction in the rate of protein synthesis in skeletal muscle, and a 44 % reduction in that in heart. Insulin treatment increased the protein synthesis rate in bot...

Journal: :British journal of anaesthesia 1980
C E Hutchinson H G Coore

The effect of halothane anaesthesia on the activity of the mitochondrial enzyme pyruvate dehydrogenase was studied in starved lactating rats. Extracts of freeze-clamped mammary gland and liver were assayed for pyruvate dehydrogenase activity. The fraction of the enzyme in the phosphorylated inactive form was increased greatly by starvation or by streptozotocin diabetes, and halothane anaesthesi...

Journal: :physiology and pharmacology 0
سید رسول ذاکر seyyed rasoul zaker division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran سیامک بهشتی siamak beheshti division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran رضوان آقائی rezvan aghaie division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran مریم نوربخش نیا maryam noorbakhshnia division of animal sciences, dept. of biology, faculty of sciences, university of isfahan, isfahan, iran

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...

Journal: :Hypertension 2001
E M de Cavanagh F Inserra J Toblli I Stella C G Fraga L Ferder

Oxidative stress is involved in both the pathogenesis and complications of diabetes. ACE inhibitors can slow the progression of cardiac and renal impairments related to diabetes. The effect of enalapril treatment on oxidative stress and tissue injury was studied in hearts, kidneys, and livers from streptozotocin-induced diabetic rats. Twenty-four rats were divided into the following groups: str...

Journal: :Nutrients 2016
Joanna Folwarczna Aleksandra Janas Maria Pytlik Urszula Cegieła Leszek Śliwiński Zora Krivošíková Kornélia Štefíková Martin Gajdoš

Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. The aim of the study was to investigate the effects of trigonelline on experimental diabetes-induced disorders in the rat skeletal system. Effects of trigonelline (50 mg/kg p.o. daily for four weeks) were investigated in three-month-old female Wist...

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