The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins o...

The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 rag./100 gm. body weight for 7 to I0 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins ...

Hepatic cirrhosis is a complex disease in which several biological, biochemical and chemical alterations are combined, none of these alone being sufficient for diagnosis. The morphological characteristics of the final stages of cirrhosis are well known, but the initial lesions and intermediate stages still have not been fully clarified. An experimental model of hepatic cirrhosis by chronic admi...

groups. Group 1 (n = 10) continued to be on food and water ad libitum and served as control. Group 2 (n = 10) received TA (0.3 g/L) of drinking water (5, 6) and food ad libitum for 16 weeks. Group 3 (n = 10) rats received TA (0.3 g/L) and sodium selenite (4 mg/L) of drinking water (7) and food ad libitum for 16 weeks. Group 4 (n = 10) received TA (0.3 g/L) of drinking water for the first 8 week...

Introduction Thioredoxin (Trx) is an endogenous multifunctional protein with a redox-active disulfide/dithiol within the conserved active site sequence: -Cys-Gly-Pro-Cys[1]. Trx is also a stress-inducible protein whose expression is enhanced by various types of stresses, e.g., viral infection, exposure to UV light, x-ray irradiation, and hydrogen peroxide (H2O2) [2]. Furthermore, Trx is a scave...

In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA dose resulted in a marked progression of injury and 100% lethality. The objecti...

Partial hepatectomy initiates a complex pattern of cellular changes in the parenchymal cells of the residual liver. The sudden shift of the cell population from normal functional biosyntheses toward syntheses in preparation for cell division provides an ideal system for the study of various aspects of cell metabolism. The morphological and biochemical changes associated with liver restoration h...

Thioacetamide is an organosulfur compound and reasonably anticipated to be a human carcinogenic and toxic effect. Sodium selenite is considered to be an anticarcinogenic and antioxidant, therefore, the aim of study is to evaluate the toxic effect of thioacetamide and the role of sodium selenite on renal tissues by using rat model. 24 Albino wistar rats of male sex (b.w: 200±30gm) were divided i...

In the Indian system of traditional medicine (Ayurveda) it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA)-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD)...

AIMS Cirrhotic patients commonly have a liver zinc deficiency, which may aggravate liver fibrosis due to the lack of antioxidative effects of zinc. This study examined the ability of polaprezinc, N-(3-aminopropionyl)-l-histidinato zinc, to prevent fibrosis in a rat model of thioacetamide (TAA)-induced hepatic fibrosis. MAIN METHODS Liver cirrhosis was induced by orally administering TAA for 2...