نتایج جستجو برای: Toxin-binding
تعداد نتایج: 463901 فیلتر نتایج به سال:
this study was carried out to examine aflatoxin b1 (afb1) removal ability of four strains of lactic acidbacteria (lab). three indigenous (lactobacillus rhamnosus tmu094, lactobacillus fermentum tmu121and pedioccus pentosaceus tmu457) and a non-indigenous (labacillus rhamnosus ptcc1637) isolateswere studied. the strains were incubated with (afb1) at different time. the toxin residual in the supe...
Delta-toxin produced by Clostridium perfringens types B and C is a β-pore-forming cytotoxin. Here, using site-directed mutagenesis, we identified the amino acid residues that contribute to delta-toxin oligomerization binding. We replaced Lys-43 Ser-109 located in β-sandwich domain Arg-200 rim domain. Substitution of alanine for caused reductions both cytotoxicity oligomerization. However, excha...
diphtheria is a fatal disease caused by exotoxin of corynebacterium diphtheria . this toxin consists of two chains, catalytic chain (a) and binding (b) chain. by binding chain (b), the toxin binds to its receptor on numerous body cells such as myocardial, kidney and peripheral nerve cells. after entering, catalytic chain (a) inhibits protein synthesis and finally can cause cell dea...
Background and Objective: Shiga toxin (STx) is the main virulence factor in Shigella Dysenteriae type I and is composed of an enzymatic subunit STxA monomer and a receptor-binding STxB homopentamer. Shigella toxin B subunit (STxB) is a non-toxic homopentameric protein responsible for toxin binding and internalization into target cells by interacting with glycolipid (Gb3). Cholera toxi...
Background: One of the major uses of large number of laboratory animals in manufacturing the vaccines is the quality control testing of vaccines, particularly potency testing of vaccines containing the tetanus toxoids by either lethal challenge or serum neutralization tests. Recently, because of various difficulties to obtain quality laboratory animals and in adequate environmental conditions, ...
This study was carried out to examine aflatoxin B1 (AFB1) removal ability of four strains of lactic acidbacteria (LAB). Three indigenous (Lactobacillus rhamnosus TMU094, Lactobacillus fermentum TMU121and Pedioccus pentosaceus TMU457) and a non-indigenous (Labacillus rhamnosus PTCC1637) isolateswere studied. The strains were incubated with (AFB1) at different time. The toxin residual in the supe...
Background: Cholera toxin (CT), responsible for the harmful effects of cholera infection, is made up of one A subunit (enzymatic), and five B subunits (cell binding). The release of cholera toxin is the main reason for the debilitating loss of intestinal fluid. Inhibition of the B subunit (CTB) may block CT activity. Objective: To determine the effect of anti CTB-IgY against oral challenge with...
objective: verotoxin is a member of shiga toxin family. this family contains ab protein toxins with an enzymatic (a) and a binding (b) compartment. cells that have receptor (gb3) are sensitive to cytotoxic effects of toxin. it has been shown that various tumor cells have gb3 receptor and are selectively sensitive to apoptotic effect of verotoxin. studies on tumor cell lines and laboratory anima...
125I-labelled heat-labile toxin (from Escherichia coli) and 125I-labelled cholera toxin bound to immobilized ganglioside GM1 and Balb/c 3T3 cell membranes with identical specificities, i.e. each toxin inhibited binding of the other. Binding of both toxins to Balb/c 3T3 cell membranes was saturable, with 50% of maximal binding occurring at 0.3 nM for cholera toxin and 1.1 nM for heat-labile toxi...
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