INTRODUCTION Inflammatory autoimmune diseases (rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis) have a considerable impact on patients' quality of life and healthcare budgets. Biosimilar infliximab (Remsima(®)) has been authorized by the European Medicines Agency for the management of inflammatory autoimmune diseases based on...

Plug-in hybrid electric vehicle (PHEV) technology has the potential to help address economic, environmental, and national security concerns in the United States by reducing operating cost, greenhouse gas (GHG) emissions and petroleum consumption from the transportation sector. However, the net effects of PHEVs depend critically on vehicle design, battery technology, and charging frequency. To e...

Countable state space Markov cost/ reward chains, satisfying a Lyapunov-t ype stability condition, are considered in this work. For an infinite planning horizon, risk sensitive (exponential) discounted and average cost criteria are considered. The main contribution is the development of a vanishing discount approach to relate the discounted criterion problem with the average criterion one, as t...

Answers how much to order when to order. Reduced price when item is purchased in larger quantities.The first model we will present is called the economic order quantity EOQ. We will discuss two types of quantity discount contracts: all units discounts and.buy the lowest total cost quantity, save the buyer money and, in some cases, receive more goods. quantity discount model example When we buy ...

In this article, a multi objective model is presented to select and allocate the order to suppliers in uncertainty condition and in a multi source, multi customer and multiproduct case in a multi period state at two levels of supply chain. Objective functions considered in this study as the measures to evaluate suppliers are cost including purchase, transportation and ordering costs, timely del...

numerous algorithms have been proposed to solve the shortest-pathproblem; many of them consider a single-mode network and crispcosts. other attempts have addressed the problem of fuzzy costs ina single-mode network, the so-called fuzzy shortest-path problem(fspp). the main contribution of the present work is to solve theoptimum path problem in a multimodal transportation network, inwhich the co...

This paper studies a problem encountered by a buying office for one of the largest retail distributors in the world. An important task for the buying office is to plan the distribution of goods from Asia to various destinations across Europe. The goods are transported along shipping lanes by shipping companies, which offer different discount rates depending on the freight quantity. To increase ...

in this paper, we develop a freight transportation model for railway network considering hazmat transportation issue. in the transportation system considered, different customers can request for carrying hazmat and non- hazmat boxes. it is assumed that the sequence of the trains in the network is known. the objective is assigning the non-hazmat boxes and hazmat boxes to wagons of the trains so ...