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The ternary complexes containing Zn +2 , valproate, and 2,2′-bipyridine (complex 1 ) nicotinamide 2 showed anti-tumor effect on a lung cancer cell line. • Complexes cause significant reduction in growth of human epithelial cells. Complex induces apoptosis but is less selective than 2. reduces the frequency cells S phase cycle. Lung one most common types worldwide development new treatment strat...

Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...

The concomitant use of carbapenems and valproate is not recommended because carbapenems may decrease serum concentrations of valproate. Increasing the dose of valproate may not compensate for the reduction, which puts the patient at risk for recurrent seizures. Therefore, close monitoring of valproate levels is necessary when initiating a carbapenem antibiotic in patients whose condition has be...

BACKGROUND Propofol is often used as an anesthetic agent for electroconvulsive therapy (ECT). In recent studies, propofol was shown to possess significant seizure-shortening properties during ECT. "Valproate" is a mood stabilizer used mainly in the treatment of bipolar affective disorder. It is reported that valproate, being an anticonvulsant, raises the seizure threshold, thus decreases the ef...

A 36-years-old man on phenytoin, levetiracetam, and sodium valproate presented with acute confusion. Routine investigations including serum valproate and phenytoin concentration were normal. His serum ammonia concentration was raised. His valproate was held and 2 days later he recovered with concordant normalisation of serum ammonia concentration. Urea acid cycle disorder was ruled out, and a d...

    In this double blind crossover study we assessed the bioequivalence of 200 mg enteric coated sodium valproate tablets manufactured by Roozdarou with 200 mg enteric coated sodium valproate (Orlept) manufactured by Desitin, Germany. Twelve healthy male volunteers were administered a single dose of 600 mg sodium valproate manufactured by Roozdarou, followed by a similar dose of Orlept, 2 weeks...

Aim: Long-term exposure to sodium valproate, an antiepileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with antioxidant, anti-inflammatory antiapoptotic found naturally many plants. In this study, we aimed investigate the of rutin, natural on valproate-induced spleen tissue damage. 
 Materials Methods: 35 male r...