Purpose: To develop and test an integrated simulation system based on the digital Extended Cardio Torso (XCAT) phantom for 4-dimensional (4D) radiation therapy of lung cancer. Methods: A computer program was developed to facilitate the characterization and implementation of the XCAT phantom for 4D radiation therapy applications. To verify that patient-specific motion trajectories are reproducib...

The development of methods for correcting patient motion in emission tomography has been receiving increased attention. Often the performance of these methods is evaluated through simulations using digital anthropomorphic phantoms, such as the commonly used extended cardiac torso (XCAT) phantom, which models both respiratory and cardiac motion based on human studies. However, non-rigid body mot...

Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosimetry when isotopes emit single gamma rays. The manual or semi-automatic segmentation of organs is a major obstacle that slows down and limits the patient-specific dosimetry. Using digital phantoms that mimic patient’s anatomy can bypass the segmentation step and facilitate the dosi...

PURPOSE At present, techniques of 4D dose verification in radiation therapy for lung cancers associated with respiratory motion are very limited, due to either lack of patient anatomy or breathing information. The aim of this study is to develop a 4D dose verification technique based on XCAT phantom which incorporates both patient anatomy and respiratory mechanics. MATERIALS AND METHODS The 4...

PURPOSE Dual-energy CT (DECT) is arguably the most accurate energy mapping technique in CT-based attenuation correction (CTAC) implemented on hybrid PET/CT systems. However, this approach is not attractive for clinical use owing to increased patient dose. The authors propose a novel energy mapping approach referred to as virtual DECT (VDECT) taking advantage of the DECT formulation but using CT...

Purpose MR-guided radiotherapy has different requirements for the images than diagnostic radiology, thus requiring development of novel imaging sequences. MRI simulation is an excellent tool optimizing these new sequences; however, currently available software does not provide all necessary features. In this paper, we present a digital framework testing sequences that incorporates anatomical st...

Introduction: Important complications of venous thromboembolism (VTE) are a longer hospital stay, readmission, recurrence of the emboli, complications of anticoagulant therapy and death in a sever condition. In present study, the volume measurement accuracy of the medical imaging interaction toolkit (MITK) software on determining VTE in computed tomography images was evaluated....