Mehrshad Abbasi
Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - The Value of Technetium-99m Labeled Alpha-Melanocyte- Stimulating Hormone (99mTc-α-MSH) in Diagnosis of Primary and Metastatic Lesions of Malignant Melanoma
Objective(s): Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes overexpressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic...
[ 2 ] - Image-based versus atlas-based patient-specific S-value assessment for Samarium-153 EDTMP cancer palliative care: A short study
Introduction: Use of SPECT/CT data is the most accurate method for patient-specific internal dosimetry when isotopes emit single gamma rays. The manual or semi-automatic segmentation of organs is a major obstacle that slows down and limits the patient-specific dosimetry. Using digital phantoms that mimic patient’s anatomy can bypass the segmentation step and facilitate the dosi...
[ 3 ] - Papillary thyroid cancer with metastases to brain, lung and kidney: A case of dosimetry proven privilege of surgical resection of organ metastases
A 45-year-old woman presented with a headache and visual complaints. Brain MRI revealed a large mass in the right occipital cortex. The tumor was surgically removed and pathological examination showed papillary carcinoma originating from thyroid gland. She had a history of thyroid surgery 27 years ago indicating papillary thyroid cancer with central neck lymph node involvement followed by no ad...
[ 4 ] - Radiation induced myocardial perfusion abnormalities in patients with left breast cancer: A prospective study with short and long term follow up
Introduction:The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty patients with left and 20 patients with right breast cancer comprised the exposed an...
[ 5 ] - Muscle perfusion scan for prediction of anticipated diabetic foot ulceration
Introduction:We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99mTc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. T...
[ 6 ] - Sentinel lymph node biopsy correctly predicts regional lymph node recurrence in trunk malignant melanoma with multiple drainage basins
We report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (SLN) biopsy. Four peritumoral intradermal Tc-99m phytate injection was performed and SLNs were detected in both axillary and right inguinal regions. On the biopsy only the right axillary SLN was metastatic leading to right axilla...
[ 7 ] - Two-day stress-rest lower limbs perfusion scan in patients referred for myocardial perfusion imaging
Introduction: Peripheral Vascular Disease (PVD) is a major cause of morbidity and is associated with Coronary Artery Disease (CAD). We aimed to perform Lower Limb Perfusion Scan (LLPS) in patients referred for Myocardial Perfusion Imaging (MPI) and estimate prevalence of PVD in subgroups with normal and abnormal MPI results. We also compared quantitative indices of LLPS in pati...
[ 8 ] - Accuracy of modification of diet for renal disease and Cockcroft-Gault equations as compared to the radioisotope double sample method: A study in patients with acute renal failure
Introduction: We intended to assess the accuracy of re-expressed Modification of Diet for Renal Disease (MDRD) and Cockcroft-Gault (CG) equations to estimate glomerular filtration rate (GFR) in chronic kidney disease in two different etiologies of acute renal failure (ARF): acute tubular necrosis (ATN) and acute glomerulonephritis (AGN). Methods: Patients admitted for ARF or the patients compl...
[ 9 ] - The incidental lung lesion: effect of cardiac stress on the MIBI uptake in the lung mass
A discrete MIBI avid lung lesion was found in cinematic views of myocardial perfusion imaging (MPI) of a 59 year-old woman. Interestingly, the abnormal uptake in the lung was detectable only in the rest phase images and not in the images acquired in the stress phase. MPI was performed for pre-operation cardiac risk assessment before correction surgery for spinal canal stenosis. She had no...
[ 10 ] - Significance of MIBI scintigraphy in a patient with hydatid cyst and parathyroid adenoma
A 17-year-old boy with hyperparathyroidism exhibited a large cyst in the left hemi-thorax on his chest X-ray. The cyst was identified as a hydatid cyst. He was referred for biphasic methoxy isobutyl isonitrile (MIBI) parathyroid scan. A discrete ectopic parathyroid was detected in the left upper mediastinum in addition to accumulation of the MIBI tracer in the cyst wall. Using radio-guided occu...
[ 11 ] - Imaging of Clot by 99mTc-HMPAO Labeled Platelet in Animal Model Induced Thrombosis
99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical procedures. In the current study, we assessed the feasibility of the use of 99mTc-HMPAO LP for imaging of small clots in an animal model. Thrombosis was induced by application of FeCl3 solution in the distal part of the inferior vena cava (IVC) of a 6100 g anesthetiz...
[ 12 ] - Imaging of Clot by 99mTc-HMPAO Labeled Platelet in Animal Model Induced Thrombosis
99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical procedures. In the current study, we assessed the feasibility of the use of 99mTc-HMPAO LP for imaging of small clots in an animal model. Thrombosis was induced by application of FeCl3 solution in the distal part of the inferior vena cava (IVC) of a 6100 g anesthetiz...
[ 13 ] - A multi-step centrifuge method for extraction of leucocytes and preparation of Tc-HMPAO labeled leucocytes
Background: Labeled leucocytes could be used for localization of infection foci after surgeries or in inflammatory diseases including inflammatory bowel diseases. Extraction of leucocytes needs 10% Hetastarch which is not available in Iran. We provide a method employing multiple centrifuges to extract and label leucocytes with Tc-HMPAO. Methods: The study was conducted from April to June 2018 ...
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