نتایج جستجو برای: abad sub

تعداد نتایج: 210638  

Journal: :Science 2004
Joyce W Lustbader Maurizio Cirilli Chang Lin Hong Wei Xu Kazuhiro Takuma Ning Wang Casper Caspersen Xi Chen Susan Pollak Michael Chaney Fabrizio Trinchese Shumin Liu Frank Gunn-Moore Lih-Fen Lue Douglas G Walker Periannan Kuppusamy Zay L Zewier Ottavio Arancio David Stern Shirley ShiDu Yan Hao Wu

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

2013
Xu Wang Yi Yang Mingyue Jia Chi Ma Mingyu Wang Lihe Che Yu Yang Jiang Wu

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Journal: :Current Alzheimer research 2014
Koteswara R Valaasani Qinru Sun Gang Hu Jianping Li Fang Du Yaopeng Guo Emily A Carlson Xueqi Gan Shirley S Yan

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...

Journal: :Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2014
Hideki Miyachi Shiro Onozawa Koichi Akutsu Wataru Shimizu Shin-Ichiro Kumita Keiji Tanaka Satoru Murata

Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia. The therapeutic strategy for ABAD with visceral malperfusion remains controversial. Because emergent surgery has a high mortality rate, emergent endovascular treatment can be performed instead. We report a case of endovascular ...

Journal: :Annals of cardiothoracic surgery 2014
Santi Trimarchi Frederik H W Jonker Guido H W van Bogerijen Jip L Tolenaar Frans L Moll Martin Czerny Himanshu J Patel

Patients with uncomplicated acute type B aortic dissection (ABAD) can generally be treated with conservative medical management. However, these patients may develop aortic enlargement during follow-up, with the risk of rupture. Several predictors have been studied in recent years to identify ABAD patients at high risk of aortic enlargement, who may benefit from early surgical or endovascular in...

2017
Andrea Bortolato Carlo Ori Ulderico Freo

Sir, Acute type B aortic dissection (ABAD) is a life-threatening vascular emergency with an incidence estimated at 5-30 per 1 million people per year.[1] Available evidence support endovascular and surgical treatment for ABAD complicated by shock or organ damage. In uncomplicated ABAD, benefits of endovascular treatment are not well established and the preferred management mandates close clinic...

2011
Yun-An Lim Amandine Grimm Maria Giese Ayikoe Guy Mensah-Nyagan J. Ernest Villafranca Lars M. Ittner Anne Eckert Jürgen Götz

Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ) deposition in the brain. Aβ exerts its toxicity in part by receptor-mediated interactions that cause down-stream protein misfolding and aggregation, as well as mitochondrial dysfunction. Recent reports indicate that Aβ may also interact directly with intracellular proteins such as the mitochondrial enzy...

2009
Leticia Arroyo Abad

Using a new dataset, this paper presents new evidence on inequality in Latin America for the 19th century and studies the effects of factor endowments and trade on inequality. Recent research has highlighted the link between the colonial origins of inequality and its persistence in Latin America. We find that inequality varied substantially throughout the century a...

2017
Mohammad Nawaz Nasery Farhad Farzam Hidayatullah Hamidi Jamshid Sadiqi Ahmad Reshad Faizi Fazel Rahman Faizi Marzia Mohammadi Ali Abad

Mathews Journal of Case Reports Hydranencephaly Mohammad Nawaz Nasery1, Farhad Farzam1, Hidayatullah Hamidi2, Jamshid Sadiqi2, Ahmad Reshad Faizi2, Fazel Rahman Faizi2, Marzia Mohammadi2 1Radiology department, Ali Abad Teaching Hospital, Kabul, Afghanistan. 2Radiology department, French Medical Institute for Children (FMIC), Kabul, Afghanistan. Corresponding Author: Mohammad Nawaz Nasery, Ali A...

2012
Todor Ganchev Iosif Mporas Olaf Jahn Klaus Riede Karl-L. Schuchmann Nikos Fakotakis

We report on a research effort aiming at the development of an acoustic bird activity detector (ABAD), which plays an important role for automating traditional biodiversity assessment studies – presently performed by human experts. The proposed on-line ABAD is considered an integral part of an automated system for acoustic identification of bird species, which is currently under development. In...

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