نتایج جستجو برای: abl translocation

تعداد نتایج: 53824  

Journal: :international journal of hematology-oncology and stem cell research 0
fatemeh nadali pathology department, school of medicine, isfahan university of medical sciences, isfahan, iran sh ferdowsi school of allied health sciences, tehran university of medical sciences, tehran, iran p karimzadeh school of allied health sciences, tehran university of medical sciences, tehran, iran bahram chahardouli hematology-oncology and bmt research center, shariati hospital, tehran university of medical science, tehran, iran n einollahi school of allied health sciences, tehran university of medical sciences, tehran, iran sa mousavi hematology-oncology and bmt research center, shariati hospital, tehran university of medical science, tehran, iran

jak2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. a single acquired point mutation – v617f – in jak2 occurs in the great majority of patients with polycythemia vera (pv) and approximately half of the patients with idiopathic myelofibrosis (imf) or essential thrombocythemia (et). in contrast, the jak2-v617f mutation is...

Kiran Kucheria Rashmi Talwar

Chronic Myeloid Leukemia (CML) is a hematopoietic malignancy characterized by the presence ofPhiladelphia (Ph1) chromosome that results from balanced reciprocal translocation between chromosomes9 and 22 leading in the formation of bcr/abl fusion gene. The present study was conducted to evaluate cytogenetic and molecular abnormalities in CML patients at presentation and during the co...

Background and Aims: Detection of overexpression in tumor-inhibiting genes provides valuable information for leukemia diagnosis and prognosis. Chronic myeloid leukemia (CML) is a stem cell disorder determined by a well-defined genetic anomaly involving BCR-ABL translocation in the Philadelphia chromosome. Curcumin is a chemo-preventive agent for the primary cancer targets, such as the breast, p...

Journal: :international journal of hematology-oncology and stem cell research 0
m yaghmaie hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran s.h ghaffari hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran k alimoghaddam hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran a ghavamzadeh hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran s.a mousavi hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran m irvani hematology-oncology and bone marrow transplantation research center, shariati hospital,tehran, iran

introduction: reverse transcriptase-polymerase chain reaction (rt-pcr) assay is a useful tool for the detection of fusion transcript resulting from specific chromosomal translocation of the leukemia cells. a specific chromosomal abnormality, the philadelphia chromosome (ph), is present in 90% to 95% of cml patients.the aberration results from a reciprocal translocation between chromosome 9 and ...

Journal: :Molecular pharmacology 2009
Akiko Fujita Tomoyuki Shishido Yunfeng Yuan Eiji Inamoto Shuh Narumiya Naoki Watanabe

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate (STI571) is the first successful target-based drug with excellent potency against chronic myelogenous leukemia. Studies on this compound have illuminated potentials and problems of kinase inhibitors in the treatment of cancer. As found in crystal structures, STI571-bound Abe...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
J B Konopka S M Watanabe J W Singer S J Collins O N Witte

The Philadelphia chromosome (Ph1), observed in greater than 90% of chronic myelogenous leukemia (CML) patients, results from a specific chromosomal translocation involving the c-abl gene. The translocation breakpoint occurs near c-abl and correlates with the production of an altered c-abl mRNA. In the CML-derived cell line K562, Ph1 is accompanied by a structurally altered c-abl protein (P210c-...

Journal: :iranian journal of public health 0
shaghayegh sabri manouchehr keyhani mohammad taghi akbari

background: previous studies have shown that leukemogenic chromosomal translocations, including fusions between break point cluster region (bcr) and abelson (abl) are present in the peripheral blood of healthy individuals. the aim of this study was to gain insights into the genetic alterations other than bcr-abl translocation in molecular level, which cause chronic myeloid leukemia (cml). metho...

Journal: :Blood 1986
D W Popenoe K Schaefer-Rego J G Mears A Bank D Leibowitz

Chromosomal translocation is one mechanism by which cellular oncogenes may be activated during tumorigenesis. The translocation of the abl oncogene to the Philadelphia chromosome in chronic myelogenous leukemia (CML) results in a new RNA transcript that fuses sequence from chromosome 22 to sequence from the abl oncogene. This RNA presumably codes for a new abl-related protein product found in C...

2006
Andrea Biondi

Philadelphia positive (Ph+) leukemias in children include essentially all chronic myeloid leukemias (CML) and 2% to 3% of childhood acute lymphoblastic leukemias (ALLs). Ph+ leukemias are characterized by a reciprocal translocation between chromosomes 9 and 22 (Philadelphia chromosome). The translocation creates a fusion of human homologue of the Abelson Murine leukemia virus ABL on chromosome ...

Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is essential for diagnosis of CML by detection of various fusi...

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