conclusions office workers with chronic hepatitis c, treated with pegylated-interferon-α2b plus ribavirin, had work performance loss. in subjects treated with acetyl-l-carnitine supplementation we observed increased daily activity and reduced presenteeism and fatigue. acetyl-l-carnitinegroup had a smaller reduction of productivity comparing to placebo group. results significant difference were ...

Mitochondria produce reactive oxygen species that may contribute to vascular dysfunction. Alphalipoic acid and acetyl-L-carnitine reduce oxidative stress and improve mitochondrial function. In a double blind, crossover study, we examined the effects of combined alpha-lipoic acid /acetyl-Lcarnitine treatment and placebo (eight weeks per treatment) on vasodilator function and blood pressure in 36...

A large body of evidence points to the positive effects of dietary supplementation of acetyl-Lcarnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facili...

3-Hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase EC 4.1.3.4) catalyses the conversion of HMG-CoA to acetyl-CoA and acetoacetate. HMG CoA is formed both 6om leucine catabolism and by the HMG-CoA synthase reaction and plays a vital role in ketogenesis. 3-Hydroxy-3-methylglutaryl-CoA lyase deficiency gives rise to 3-hydroxy-3-methylglutaric aciduria and affected patients are unable to synthesis...

Variations in energy balance, body composition, and nutrient partitioning induced by acetyl-Lcarnitine (ALCAR) supplementation were studied in young (2 mo) and old (24 mo) Wistar rats. Changes in skeletal muscle metabolism as well as in serum free triiodothyronine and leptin levels were also evaluated. Rats were administered 0 (control) or 15 g/L ALCAR in their drinking water for 1 mo. ALCAR tr...

Fragile X syndrome (FXS) is a triplet repeat disorder caused by a large expansion of the CGG repeat in the 5′-untranslated region (UTR) of the fragile X mental retardation (FMR1) gene. 2 Full mutation alleles are almost always associated with extensive hypermethylation of the repeat and of the upstream CpG island, which correlates with gene silencing and absence of the FMR1 protein. Cognitive f...

Suppression of PentylenetetrazolInduced Seizures and c-fos Expression in Mouse Brain by L-Carnitine: Yoshihisa IRYO, et al. Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health—Seizure development in ddY mice was recorded on a videotape for 20 min after injection of pentylenetetrazol (PTZ) (50 mg/kg) and analyze...