Chronic administration of acrylonitrile results in a dose-related increase in astrocytomas in rat brain, but the mechanism of acrylonitrile carcinogenicity is not fully understood. The potential of acrylonitrile or its metabolites to induce direct DNA damage as a mechanism for acrylonitrile carcinogenicity has been questioned, and recent studies indicate that the mechanism involves the inductio...

Acrylonitrile is a potent mutagen and carcinogen for hepatocytes. A role of toll-like receptor 4 in the immune toxicity of acrylonitrile has been suggested in many studies. The following study was designed to assess the quantitative alteration of toll-like receptor 4 under the influence of sodium thiosulfate which was used to antagonize acrylonitrile-induced immune toxicity in rats. 70 Sprague ...

The previously claimed (1) catalysis of the electroreduction of acrylonitrile by means of a complex of Co(l) and 2,2'-bipyridine is shown to be erroneous. The "catalytic currents" result instead from the two-electron reduction of a mixed complex of Co (I) acrylonitrile and 2,2' -bipyridine. The equilibrium and forward rate constants for the formation of the mixed complex have been estimated and...

Acrylonitrile is an IARC class 2B carcinogen present in cigarette smoke. Urinary 2-cyanoethylmercapturic acid (CEMA) is an acrylonitrile metabolite and a potential biomarker for acrylonitrile exposure. The objective of this work was to study the dose response of CEMA in urine of non-smokers and smokers of different ISO tar yield cigarettes. We observed that smokers excreted >100-fold higher amo...

Exposure to acrylonitrile, a high-production industrial chemical, can promote noise-induced hearing loss (NIHL) in the rat even though this agent does not itself produce permanent hearing loss. The mechanism by which acrylonitrile promotes NIHL includes oxidative stress as antioxidant drugs can partially protect the cochlea from acrylonitrile + noise. Acrylonitrile depletes glutathione levels w...

Corrosion inhibition of Cu10Ni alloy in 0.5 M HCl solution using acrylonitrile derivatives namely: (E)-2(1H-indole-3-carbonyl)-3-(2-oxo-2-phenylethylthio)-3-(phenylamino)acrylonitrile(a),(E)-2-(1H-indole-3carbonyl)-3-mercapto-3-(phenylamino)acrylonitrile(b)and(Z)-2-(1H-indole-3-carbonyl)-3 phenylacrylonitrile (c) was investigated by potentiodynamic polarization, electrochemical impedance spectr...

We synthesized three novel highly fluorescent compounds, 2-(2'-pyridyl)-3-(N-ethyl-(3'-carbazolyl))acrylonitrile, 2-(3"-pyridyl)-3-(N-ethyl-(3'-carbazolyl))acrylonitrile, and 2-(4-pyridyl)-3-(N-ethyl-(3'-carbazolyl))acrylonitrile by Knoevenagel condensation. The first two were synthesized without solvent in the presence of piperidine as a catalyst; the third was synthesized without a catalyst a...

AIM OF THE STUDY The aim of the study was to check the stress absorbed by the bone around mini over-denture dental implant with and without acrylonitrile O-ring under two different loading conditions. The initial stress absorbed by the implant plays a significant role in the success of the immediate loading implants. MATERIALS AND METHODS A three-dimensional finite element analysis using Pro-...

Monitoring of the content of free acrylonitrile in plastics used for the preparation of viands is necessary due to its negative effect on human health. A content of 20 ppb is the maximal value of free acrylonitrile in such samples. In this case, head-space gas chromatography is most favourable analytical method when combined with the standard addition method together with a mass-spectrometry de...