background: the role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it. in this study, we determined serum uric acid levels in patients with acute stroke and assessed its relationship with cerebrovascular risk factors. methods: in this cross sectional study, we assessed patients with acute stroke who were admitted in fi...

objective(s) the purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (vpa) in bipolar patients in comparison with those of epileptic patients. materials and methods ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. blood samples were c...

background: the treatment of acute promyelocy!c leukemia with all-trans-re!noic acid (atra) some!mes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural or pericardial effusion, and pulmonary infiltrates. we report the major clinical and radiologic features of atra syndrome. materials and methods: in the past, occasional case reports and literature pertainin...

acute leukemia is characterized by the accumulation of neoplastic cells in the bone marrow and peripheral blood. currently, chemotherapy and differentiating agents have been used for the treatment of leukemia. recently, plant extracts, either alone or in combination with chemo agents, have been proposed to be used for the treatment of cancers. the aim of the present research was to study the cy...

abstract background: screening for patients at risk of renal scarring is a challenge in children with acute pyelonephritis (apn). diuretic tc-99m mercaptoacetyltriglycine (mag3) scintigraphy with zero time injection of furosemide (mag3-f0) was observed to display focal parenchymal disorders. the advantages of mag3 include: lower radiation dose and short duration of the test. the aim of this stu...

urinary tract infection (uti) may lead to irreversible changes in renal parenchyma. early diagnosis using scintigraphy with technetium-99 m -labeled dimercaptosuccinic acid (dmsa) scan and early treatment may decrease or prevent development of renal parenchymal lesions. the aim of this study was to assess the occurrence of renal parenchymal lesion in children admitted with a first-time symptoma...

changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. in this the study, serum level of gamma aminobutyric acid (gaba) and l-arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. serum gaba was measure...

introduction: traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million people across the globe. most of these patients are young and active people suffering disabilities. tranexamic acid (txa) therapy is commonly used to reduce blood loss and need for blood transfusions in surgical cases. this study aimed at investigating the effect of tranex...

patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...

background: impact of high level of uric acid on stroke is still controversial. we conducted this study to investigate the relationship between acute ischemic non-embolic stroke and serum levels of uric acid. methods: this was a case-control study on patients with acute ischemic non-embolic stroke in rafsanjan, iran. the control group consisted of normal persons who were similar to the case gro...