Introduction: Collimating the primary beam to the area of diagnostic interest (ADI) has been strongly recommended as an effective method to reduce patient’s radiation dose and to improve image quality during radiology practice. Lack or inadequate collimation results in excessive radiation dose to patients and deterioration image quality.Objective: To assess the quality of beam collimation dur...

In this paper, we conduct a simulation study to evaluate the impact of using imperfect advance demand information (ADI) in a single stage production/inventory system. We mean by ADI the fact that the production system receives customer orders in advance of their due-dates. We consider four types of ADI: 1) Perfect ADI, 2) ADI with imperfect due-dates, 3) ADI with imperfect demand quantities and...

OBJECTIVE IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG aDI in vivo. In this proof-of-concept study, we designed a novel system to affinity purify polyclonal aDI aPL in order to assess its...

A new Peaceman–Rachford alternating direction implicit (PR-ADI) method is proposed in this work for solving two-dimensional (2D) parabolic interface problems with discontinuous solutions. The classical ADI schemes are known to be inaccurate for handling interfaces. This motivates the development of a matched Douglas ADI (D-ADI) method in the literature, in which the finite difference is locally...

This study examined the stability of scores on the ADI-R from pre-school to elementary school age in children with autism spectrum disorders (ASD). Participants were 35 children who, at T1, all had a clinical diagnosis of ASD. On initial assessment (mean age 3.5 years; SD 0.6 years), all met ADI-R algorithm criteria for autism. ADI-R assessments were repeated at follow up (FU; mean age 10.5 yea...

Arginine deprivation as an anticancer therapy has historically been met with limited success. The development of pegylated arginine deiminase (ADI-PEG20) has renewed interest in arginine deprivation for the treatment of some cancers. The efficacy of ADI-PEG20 is directly correlated with argininosuccinate synthetase (ASS) deficiency. CWR22Rv1 prostate cancer cells do not express ASS, the rate-li...

Arginine starvation has the potential to selectively treat both primary tumor and (micro) metastatic tissue with very low side effects. Arginine deiminase (ADI; EC 3.5.3.6), an arginine-degrading enzyme, has been studied as a potential anti-tumor drug for the treatment of arginine-auxotrophic tumors. Though ADI-PEG20 (pegylated ADI by PEG 20,000) already passed the phase I/II clinical trials [1...

From 1996 to 2003, four 12-month population-based surveys were performed in FoodNet sites to determine the burden of diarrhoeal disease in the population. Acute diarrhoeal illness (ADI) was defined as > or =3 loose stools in 24 hours with impairment of daily activities or duration of diarrhoea >1 day. A total of 52840 interviews were completed. The overall weighted prevalence of ADI in the prev...

UNLABELLED Streptococcus pyogenes (group A Streptococcus [GAS]) causes ~700 million human infections/year, resulting in >500,000 deaths. There is no commercial GAS vaccine available. The GAS surface protein arginine deiminase (ADI) protects mice against a lethal challenge. ADI is an enzyme that converts arginine to citrulline and ammonia. Administration of a GAS vaccine preparation containing w...