Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear. We evaluated plasma adiponectin levels in 32 first-episode drug-naïve major depression (DSM-IV-TR) patients without conventional ...

Acute myocardial infarction (AMI) refers to ST-elevated and non ST elevation infarction, is the known presentation of coronary artery disease. Study was planned explore interplay adipokines, resistin / lipoprotein (a) prognosis in middle old age female patients with Non Elevation Myocardial Infarction. Material Methods: A cross-sectional study conducted on 150 acute (AMI). Consented were divide...

Adiponectin is an adipocyte-derived hormone that acts as a major regulator of energy metabolism and insulin sensitivity (1, 2). In plasma, adiponectin occurs in different forms: the trimeric low molecular weight (LMW), the hexameric middle molecular weight (MMW) and the 12-18meric high molecular weight (HMW) complexes (3). Adiponectin can be found in a smaller globular form, which is produced t...

Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., ratio) of multimeric forms with key features of the metabolic syndrome. Total a...

Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...

OBJECTIVE To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults. RESEARCH DESIGN AND METHODS Total and HMW adiponectin were measured in a population-based study of older adults. The relations of total adiponectin, HMW adiponectin, and their ratio with incident diabetes (n = 309) were as...

INTRODUCTION Adiponectin plays an important role in the regulation of tissue inflammation and insulin sensitivity. Perturbations in adiponectin concentration have been associated with obesity and the metabolic syndrome. Data on adiponectin pathophysiology in critical illness are limited. METHODS Twenty three critically ill patients (9 severe sepsis, 7 burns, 7 trauma). Adiponectin assays on D...