background: sickle-cell anemia is characterized by defective hemoglobin synthesis with production of sickle hemoglobin. sickle red blood cells become deformed and rigid with difficulty to pass through narrow capillaries and frequent clotting and thrombosis leading to repetitive vascular occlusions and progressive organ damage. we conducted this work to study some adrenal functions using acth st...

Introduction: Psychological stresses influence brain functions such as learning and memory. Environmental factors like types and durations of stress affect brain responsiveness. This study investigated the effects of two subchronic social and isolation stresses on learning, memory, adrenal glands weight and corticosterone levels in the hippocampus and frontal cortex. Methods: Eighteen male ...

Introduction: Glucocorticoids are considered the cornerstone of the induction phase in all treatment protocols of acute lymphoblastic leukemia (ALL). Among the adverse effects of high-dose glucocorticoid treatment, adrenal insufficiency is secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This drawback of exogenous steroid therapy gains a contemporary particular relevan...

LABORATORY DATA adrenal changes phaeochromocytoma adrenal cortex hormones adrenal insufficiency, adrenal hypoplasia aldosterone, high levels chromosomal assignment chromosome 11q localization chromosome 3p localization gene, structural-functional anomalies CCND1 (PRAD1) cyclin D1, gene chr.11q13 gene analysis-DNA analysis ST11 (PETS1), gene chr.3p25 VHL von Hippel-Lindau syndrome, gene chr.3p26...

Pheochromocytomas can be a part of familial neoplastic syndromes, in which case they tend to be multiple and involve both adrenal glands. Therefore, sparing adrenocortical function represents a major concern while dealing with these hereditary lesions. Herein, we describe the clinical characteristics and the management strategy of a patient with von Hippel-Lindau (VHL) disease who had multiple,...

Primary adrenal lymphoma (PAL) is uncommon in clinical settings, which is considered a rare high grade malignant lymphoma with a poor prognosis, patients with bilateral mass are rarer, and patients with normal adrenal function are extremely rare. We present 2 cases of patients with bilateral adrenal primary diffuse large B-cell lymphoma (PA-DLBCL) whose adrenal functions were normal. 2 patients...