TAKAHASHI,K.Adrenomedullin from a Pheochromocytoma to the Eye:Implications of the Adrenomedullin Research for Endocrinology in the 21st Century. Tohoku J.Exp.Med.,2001,193(2),79-114 In the last several decades,the concept of“endocrinology”has been greatly changed.One major change was due to the discovery of peptide hormones secreted by the organs that were not “classical”endocrine organs.For ex...

OBJECTIVE To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats). METHODS Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation...

objective(s): the study aimed to investigate the effects of adrenomedullin (adm) and proadrenomedullin n- terminal 20 peptide (pamp) on angiotensin ii (angii)-stimulated proliferation in vascular smooth muscle cells (vsmcs). materials and methods: thoracic aorta was obtained from wistar rats and vsmcs were isolated from aorta tissues and then cultured. in vitro cultured vsmcs were stimulated wi...

Diabetes is a major threat to global public health. According to the latest data from the International Diabetes Federation (IDF), at least 366 million people are living with diabetes and this number is projected to be 552 million by 2030. At least 50% of people with diabetes suffer from one or two major diabetic complications such as diabetic cardiomyopathy, nephropathy, neuropathy, retinopath...