Background: Triple-negative breast cancer (TNBC) is a great threat to global women's health due its high metastatic potential. Epithelial-to-mesenchymal transition (EMT) considered as key event in the process of metastasis. So pharmacological targeting EMT might be promising strategy improving therapeutic efficacy TNBC. Here, we investigated effect shikonin exerting on and consequently metastas...

The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members this serve as biomarkers and targets systemic therapy. Tissue primary from treatment-naïve PeCa patients was used tissue microarray analysis. Immunohistochemical staining performed with antibodies against AKT, pAKT, mTOR, pmTOR, pS6, pPRAS, p4EBP1, S6K1 pp70S6...

objective(s):the purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (cp)-induced renal damage in rats. materials and methods: fourteen adult sprague dawley rats, weighing 200 to 210, were administered by cisplatin (cp, 2 mg/kg/day) twice a week for five weeks. then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day...

Objective(s): Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegeneration in rats. Materials and ...

Purpose: To study the effects of anisodamine (Ad) combined with lidocaine (Ldc) on myocardial ischemia-reperfusion injury (MIRI) in rats, and its correlation PI3K/AKT signaling pathway.Methods: A total 70 healthy rats were randomly divided into S group, M Ad Ldc + LY group. The cardiac hemodynamic indices each group determined, area infarction measured. Serum biochemical also determined. Furthe...


 Purpose: To study the influence of oxymatrine on hypoxic-ischemic brain injury (HIBI) in neonatal rats.
 Methods: Newborn SPF Sprague-Dawley (SD) rats were randomly assigned to 3 groups (10 rats/group): control, HIBI and groups. Neurobehavioral latency each rat was determined after 48 h treatment, pathological changes cerebral cortex evaluated using H&E staining. Hippocampal neu...

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...