The phosphoinositide-3-kinase/Akt (PI3K/AKT) signaling pathway is crucial for Sertoli cell development and completing spermatogenesis. Its main role to promote proliferation inhibit apoptosis. Many factors activate the PI3K/AKT pathway, like hormones, such as follicle stimulating hormone (FSH), androgen, estrogen, insulin name a few. of these have receptors inside or on surface cells (SCs). Thi...

Glutamate, as an essential neurotransmitter, has been thought to have different roles in the central nervous system (CNS), including nerve regeneration, synaptogenesis, and neurogenesis. Excessive glutamate causes an up-regulation of the multiple signaling pathways, including phosphoinositide-3 kinase/protein kinase B (PI3K/Akt), Akt/mammalian target of rapamycin (mTOR) protein, mitogen-activat...

Prostate cancer (PC) is one of the prevalent tumors in men causing higher mortality. Luteoloside has been discovered for suppressive role into progression some cancers. However, Luteoloside’s regulatory functions regarding PC are not well understood. This study thus designed to investigate impact on progression. In this work, it was demonstrated that cell proliferation gradually inhibited with ...

Background: MicroRNAs (miRNAs) can play essential roles in the modulation of cancer cell growth, survival, and resistance to chemotherapy. Thus, we hypothesized that restoration miR-451a-5p (a tumor suppressor) might affect sensitivity chemotherapeutics breast cells. Methods: For this purpose, malignant cells (MDA-MB-231) were transfected with mimic exposed carboplatin. Then, apoptotic rate was...

Abstract BACKGROUND Mutations of the isocitrate dehydrogenase (IDH) gene are highly prevalent in WHO II/III glioma. IDH-mutated glioma frequently exhibits strong molecular signatures PI3K/AKT/mTOR signaling, whereas precise roles this oncogenic pathway remain elusive. METHODS In study, we performed unbiased RNA sequencing and set enrichment analysis (GSEA) to investigate relevant pathways gover...

Abstract Radix puerariae has become the most commonly used medicine for diabetic nephropathy (DN). However, mechanism of in treatment DN is not completely clear. This study to determine active ingredients, targets, and signaling pathways using network pharmacology analysis animal experiments confirm its possible action. A total 12 potential effective components 10 key therapeutic targets were o...

Background. The radioresistance of glioma stem cells (GSCs) is related to some microRNAs (miRs) generated by radiation. This study aimed investigate the effects miR-17-5p and miR-130b-3p on radiosensitivity GSCs. Methods. expressions in SU3 SU3-5R were determined. transfected with or mimics inhibitors used determine cell viability after irradiation as well examine changes supernatant glucose, i...

MicroRNAs (miRNAs/miRs) serve an important role in the pathogenesis of chronic heart failure (CHF). A number reports have illustrated regulatory effect serum exosomal miRNA on myocardial fibrosis. The present study aimed to investigate expression miR‑320a exosomes, as well fibroblast proliferation. Serum exosome samples from 10 patients with CHF and 5 healthy volunteers were obtained characteri...

Activation of hepatic stellate cells (HSC) leads to initiation and progression fibrosis. HSC senescence is inversely correlated with proliferation activation. Therefore, induction may be a strategy treat Coumarin-derivatives like esculetin have been suggested inhibit fibrogenic cells. in this study we aimed investigate the effect on activation . Primary rat were used all experiments. Real-time ...