abstract objectives: interruption of rennin-angiotensin-aldosterone system has become a leading therapeutic strategy in the treatment of diabetic nephropathy however, aceis and arbs do not uniformly suppress the rennin-angiotensin-aldosterone system. plasma aldosterone levels are elevated in a group of patients despite therapy and this phenomenon known as aldosterone escape or aldosterone break...

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

There are many reports for involvement of ATP-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. This study examined the effect of single doses of K+ channel openers diazoxide, minoxidil and K+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. Blood samples were obtained 60 minutes after drug treatment and serum...

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

Background: Aldosterone has been assumed to be implicated in left ventricular hypertrophy (LVH). Preventing the progression of LVH in the early period of end-stage renal disease (ESRD) can increase patient survival. In this study, therefore, we analyzed the relationship between aldosterone level and LVH in ESRD patients who underwent hemodialysis at Fatemeh Zahra Hospital and Imam Khomeini Hosp...

accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...

there are many reports for involvement of atp-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. this study examined the effect of single doses of k+ channel openers diazoxide, minoxidil and k+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. blood samples were obtained 60 minutes after drug treatment and serum...

- pseudohypoaldosteronism (p'ha) is referred to a state of endorgan unresponsiveness to aldosterone. in this article a 12 day - old mule newborn is presented with hyponatremia, hyperkalemia and metabolic acidosis. aldosterone level and plasma renin activity were high. mineralocorticoids had no therapeutic effect, hut normal saline infusion improved electrolyte imbalance. salt-rich diet was succ...

Abstract Objectives: Interruption of rennin-angiotensin-aldosterone system has become a leading therapeutic strategy in the treatment of diabetic nephropathy however, ACEIs and ARBs do not uniformly suppress the rennin-angiotensin-aldosterone system. Plasma aldosterone levels are elevated in a group of patients despite therapy and this phenomenon known as aldosterone escape or aldosterone brea...

Aldosterone is one of the most essential hormones synthesized by adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) a newly discovered aldosterone receptor, which proposed to mediate non-genomic pathways while hormone simultaneously interacts with mineralocorticoid receptor. In contrast its cardio-protective role in postmenopausal women ...