It is well known that when alloxan is injected intravenously into rabbits, dogs, and monkeys an initial hyperglycemia is followed by a transient hypoglycemia, leading to death of the animals from hypoglycemic convulsions. If the hypoglycemia is prevented by repeated intravenous injections of glucose, the animals survive and permanent hyperglycemia and diabetes develop. The cause of the transien...

It was the purpose of this investigation to determine the ultraviolet absorption spectra of alloxan and dialuric acid. Previous investigators (l-3) reported that these substances had absorption spectra without definite maxima. However, since preliminary studies indicated that maxima were present under certain conditions, it was thought that a more careful investigation should be made. Although ...

BACKGROUND Croton lobatus contains a high amount of antioxidant phytochemicals that probably account for its wide use as food and medicine in the traditional communities of West Africa. METHODS The study evaluated the modulatory role of methanol extract of Croton lobatus leaf on alloxan-induced diabetes and associated cardiovascular complications. Male rats were randomly selected and assigned...

In addition to causing necrosis of /?-cells, diabetogenic doses of alloxan or streptozotocin cause selective autophagy and destruction of /^-granules in intermediate cells in the rat pancreas, thus providing evidence that these granules and those in the /?-cells of the islet are identical. In acinar-/? cells the autophagic vacuoles also contain small mitochondria similar to those that occur in ...

Glucokinase (GK) is hypothesized to be the critical glucosensor of pancreatic beta-cells and hypothalamic glucosensing neurons. To understand the role of GK in glucoprivic counterregulatory responses, we injected alloxan, a GK inhibitor and toxin, into the third ventricle (3v) to target nearby GK-expressing neurons. Four and 6 days after 3v, but not 4v, alloxan injection, alloxan-treated rats a...

Oxidative stress induced by alloxan has been shown to damage pancreatic beta-cell and produce hyperglycemia in rats. Aegle marmelos leaf extract is being used in Ayurveda as a medicine for diabetes. The present study examined the action of Aegle marmelos against experimental diabetes as well as the antioxidant potential of the drug. A methanolic extract of Aegle marmelos was found to reduce blo...

Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner a...

The mechanism of the production of diabetes in animals given injections of alloxan has been the subject of much study in recent years. Since the original publication of Dunn, Sheehan & McLetchie (1943) it has been established that the diabetes is pancreatic in origin but the chemical mechanisms involved have remained in doubt. Leech & Bailey (1945), using the arsenophosphotungstic acid method, ...

background & aim: diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. experimental: this study aimed at assessing ...

The antidiabetic effect of an aqueous seed extract of Syzygium calophyllifolium Walp. was studied in alloxan induced diabetic rats. Changes in serum and tissue AST, ALT LDH, ACP and ALP, enzymes activities in alloxan induced rats were studied and found to be reversed by the oral administration of S.calophyllifolium seed extract.