abstract   introduction: inflammation and wear debris may be responsible for bone lysis and subsequent lost in aseptic arthroplasty. prostaglandin e2, platelet activating factor, and histamine are important mediators of inflammatory cells. we studied histopathological changes of cement-bone interface after using specific antagonists of these mediators.   methods: left and right tibiae of 120 ra...

Objective: The objective of the study was to comparison alprazolam versus clonidine and pregabalin as pre-anesthetic medication in patients undergoing elective lower limb surgeries. Methods: present undertaken compare effects 0.5 mg, 100 μg, 75 mg premedicant drugs for reduction pre-operative anxiety. 90 ASA Grades I II, between 18 60 years, either sex, surgery were divided into three groups 30...