O Alprazolam e um farmaco da classe dos benzodiazepinicos reconhecido pela ANVISA, eficaz no tratamento transtornos de ansiedade pânico. Entretanto o uso nao racional, causado falta orientacao profissional adequada, pode resultar problema dependencia pelo medicamento. Neste estudo, atraves analise qualitativa, carater descritivo, bibliografia diversos autores sobre os efeitos nocivos do raciona...

The respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO(2) and pulse oxim...

STUDY OBJECTIVE To evaluate the effect of a standardized meal on the bioavailability of alprazolam formulated as an immediate-release orally disintegrating tablet (ODT) in healthy volunteers. DESIGN Single-dose, randomized, open-label, two-period crossover study. SETTING Contract research organization clinic. SUBJECTS Sixteen healthy volunteers (seven men, nine women), aged 20-50 years. I...

BACKGROUND The 'off-label' effect of alprazolam on depression has not been systematically evaluated. OBJECTIVES To determine the antidepressant effect, including tolerability and acceptability, of alprazolam as monotherapy for major depression, when compared to placebo and conventional antidepressants in outpatients and patients in primary care. SEARCH METHODS We searched the Cochrane Centr...

Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation and anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg and the other taking placebo daily for two weeks. We utilized the Cambridge Neuropsychological Test Automated Battery (CANTAB) softw...

Alprazolam differs from other benzodiazepines by the incorporation of a triazolo ring in the basic chemical structure. Several lines of evidence have supported that alprazolam and standard antidepressants have some similar actions, such as beta-adrenergic receptor down-regulation, antipanic effect. Because of the difference in opinions pertaining to the antidepressant effect of alprazolam, this...

This study was designed to determine whether age influences sensitivity to alprazolam and/or rate of acute tolerance development to the effects of alprazolam. Three treatments were each separated by 4 weeks. Twenty-five young (ages 22-35) and 13 elderly (ages 65-75) men received 2 mg of alprazolam/2 min i.v. Blood samples were obtained over 48 hr, and sedative, psychomotor and memory effects we...

This paper describes a gas chromatography-mass spectrometry (GC-MS) method for determination of alprazolam in rabbit plasma. Alprazolam and internal standard (IS) medazepam were extracted from plasma by using liquid-liquid extraction method. The samples were separated by GC on a DB-5MS analytical column and determined by a quadrupole mass spectrometer detector operated under selected ion monito...

INTRODUCTION Alprazolam is a triazolobenzodiazepine used in panic disorders and other anxiety states. Target organ of Alprazolam is CNS, causing depression of respiration and consciousness. AIM This study aimed to estimate the genotoxic potential of Alprazolam using Allium cepa test. METHODS Allium cepa is one of the most suitable plants for detecting different types of xenobiotics. The tes...