16 November 2006. Everyone with even a passing interest in Alzheimer disease has seen a sepia-toned photograph of its namesake like the one on last week’s cover of Science magazine. A fatherly, pensive man with a mustache, sometimes a cigar, photographed from his right side and often with hands folded in his lap as was customary for sitting portraits at the time. But there is much more to Alois...

IMPORTANCE Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer disease in African American individuals is unknown. Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment. OB...

A short history of Alzheimer disease and vascular dementia is presented. The socio-medical events that led to the dominance of Alzheimer disease are discussed. Alzheimer's contributions to our current understanding of vascular dementia are reviewed.

Demansın en yaygın şekli olan Alzheimer hastalığı, hafıza kaybı ve diğer bilişsel problemler ile karakterize karmaşık bir hastalıktır. Artan prevalansa sahip hastalığının fizyopatolojisinin anlaşılması bu hastalığın tedavisinde etkin bileşiklerin yapılarının araştırılması, yeni ilaç moleküllerinin geliştirilmesine yardımcı olacaktır. Bu anlamda hastalık üzerinde etkili hipotezlerin, yapısının e...

Fondation Recherche Alzheimer (SAO-FRA 2019/0025)was missing from the acknowledgements. This has been corrected online.

IMPORTANCE The clinical role of amyloid brain positron emission tomographic imaging in the diagnosis of Alzheimer disease is currently being formulated. The specificity of a positive amyloid scan is a matter of contention. OBSERVATIONS An 83-year-old Canadian man presented with a 5-year history of predominantly short-term memory loss and functional impairment. Clinical evaluation revealed sig...