alzheimer is age-related, progressive brain degeneration disease. it destroys memory slowly. the number of people living with ad is increasing as fast as the count of aged population and extension of bad nutrition habits. the main cause of ad is not clearly known, but prior studies noted the importance of inflammation in tau hyperphosphorylation and failure of microglia to clear ab peptide accu...

background: the seladin-1 (selective alzheimer disease indicator-1), also known as dhcr24, is a gene found to be down-regulated in brain region affected by alzheimer disease (ad). whereas, hair follicle stem cells (hfsc), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. our aim was to evaluate...

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in...

abstract alzheimer’s disease (ad) is the most common cause of dementia in elderly people. the prevalence of alzheimer diseases is increasing in the world due to population aging. metabolic disease such as diabetes and obesity play important role in alzheimer disease. hyperglycemia can play important role in brain damage. it causes cognitive impairments, functional and structural alterations in ...

Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and short- term (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups 1) intact, 2) sham, 3) sham-Alzheimer 4) ...

    Background: Nowadays, Alzheimer’s disease (AD) is considered as Type 3 diabetes in which insulin resistance is the common cause of both diseases. Disruption of insulin signaling cascade and insulin resistance can induce AD; and central insulin resistance causes systemic alterations in serum insulin, FBS levels, and lipid profile. Studies have shown that probiotics (Lact...

alzheimer disease (ad) is a neurodegenerative disorder and the most common form of dementia. increasing evidence suggests that alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. in vitro and animal studies have linked neuroinflammation to alzheimer's disease (ad) pathology. studie...

conclusions according to iranian traditional medicine, the brain dystemperement is considered the main causes of alzheimer disease. by correcting the brain dystemperement, alzheimer can be well managed. this study helps to suggest a better strategy for preventing and treating alzheimer in the future. results findings showed that alzheimer disease has the most overlap with nesyan (fisad-e-zekr, ...

background: alzheimer’s disease (ad) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. the aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of ad. methods: adult male albino wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. the rats were randomly assigned t...