نتایج جستجو برای: aminonitriles

تعداد نتایج: 72  

2011
Debasish Bandyopadhyay Juliana M Velazquez Bimal K Banik

BACKGROUND The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds. RESULTS Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This genera...

Journal: :The Journal of organic chemistry 2003
Mark McLaughlin Rafat M Mohareb Henry Rapoport

The preparation of O-methylimidates from alpha-aminonitriles and their subsequent co-cyclization with primary amines to afford 4-substituted 5-aminoimidazoles was studied. It was found that the mildly acidic pyridinium p-toluenesulfonate efficiently catalyzed each stage of the reaction sequence: (a) the formation of the O-methylimidates, (b) their co-cyclization with a variety of primary amines...

Journal: :Journal of the American Chemical Society 2008
Shun-ichi Murahashi Takahiro Nakae Hiroyuki Terai Naruyoshi Komiya

Ruthenium-catalyzed oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid gives the corresponding alpha-aminonitriles, which are highly useful intermediates for organic synthesis. The reaction is the first demonstration of direct sp(3) C-H bond activation alpha to nitrogen followed by carbon-carbon bond formation under aerobic oxidation c...

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 1999
mohammad m. hashemi behnaz almasi

addition of potassium cyanide to a mixture of schiff base and lithium perchlorate afforded a-aminonitriles in high yields. addition of potassium cyanide to a methanolic solution of schiff base and phosphoric acid afforded a-aminonitriles. when the reaction mixture was refluxed it gave a-amino acids in high yields.

2012
Piotr Milart Janusz Sepiol

The reaction of arylidenemalonodinitriles 1 with 1-arylethylidenemalonodinitriles 2 gives rise to sub­ stituted cyclohexadiene derivatives 3 which then undergo elimination of hydrogen cyanide and afford 3,5-diaryl-2,6-dicyano-aminobenzenes 4. This reac­ tion is a modification of more general dimerization reaction involving ylidenemalonodinitriles synthe­ sized from a variety of ketones. These t...

Journal: :European Journal of Organic Chemistry 2021

Two representative members of the phenanthropiperidine alkaloid family, tylophorine (1) and cryptopleurine (2), were synthesized by a bidirectional alkylation strategy employing dibenzylaminoacetonitrile as substrate. This approach relies on unprecedented condensation metallated α-aminonitriles with bromomethylphenanthrenes to provide fully substituted α-aminonitriles, which are subjected NaBH4...

Journal: :Asian Journal of Organic Chemistry 2023

The functional group transformation associated with nitrile moiety is considered a diligent research topic in the synthetic community as it building block for several organic molecules, including ketones and amides. Many methodologies have been developed synthesizing amides, considering them analogues exciting biological properties. However, there are limited articles to synthesize these import...

Journal: :Organic & biomolecular chemistry 2010
Guang-Wu Zhang Dong-Hua Zheng Jing Nie Teng Wang Jun-An Ma

A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of alpha-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.

2014
Nicola Otto Till Opatz Helmut Ringsdorf

Owing to their various modes of reactivity, aaminonitriles represent versatile building blocks for the construction of a wide range of nitrogen heterocycles. The present Concept article focuses on synthetic methodologies using their bifunctional nature which is the basis of their reactivity as a-amino carbanions and as iminium ions. Reactions exclusively taking place on either the amine or on t...

Journal: :Chemical communications 2011
Yan Zhang Hao Peng Ming Zhang Yixiang Cheng Chengjian Zhu

Oxidative α-cyanation of tertiary amines is catalyzed by gold complexes with trimethylsilyl cyanide to afford the corresponding α-aminonitriles in the presence of tert-butyl hydroperoxide in good to excellent yields under acid-free conditions at room temperature.

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