Tricyclic antidepressants have a long history in the treatment of headache. In 1964 Lance and Curran reported a better response to amitriptyline (30-75 mg/day) in chronic tension headache (n=280) compared with 11 other commonly used drugs (such as benzodiazepines, vasodilators, and sedatives). They also reported a placebo controlled crossover trial of 27 patients that showed clinically signific...

Purpose. This study was designed to investigate the action of amitriptyline, a tricyclic antidepressant, on airway smooth muscle reactivity and its underlying mechanisms. Methods. In isolated rat trachea, isometric force was recorded to examine the effects of amitriptyline on contractile response to acetylcholine (ACh), electrical field stimulation (EFS), calyculin A (myosin light chain phospha...

PURPOSE Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are involved in hepatic injury. Melatonin is an antiaging and antioxidant hormone synthesized from pineal gland. The aim of present study was to ev...

BACKGROUND Pain after amputation is common but difficult to treat, and few controlled treatment studies exist. METHODS In the current study, 94 treatment-naive posttraumatic limb amputees with phantom pain (intensity: mean visual analog scale score [0-100], 40 [95% confidence interval, 38-41]) were randomly assigned to receive individually titrated doses of tramadol, placebo (double-blind com...

The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD). Forty-seven women (mean age = 35.4 years old) with chronic TMD were enrolled in the study and divided into 4 groups: amitriptyline; amitriptyline and CBT; placebo and CBT; and placebo...

BACKGROUND Pain in the rectal, genital, and perineal area is a common condition treated by pain physicians. These chronic pain syndromes are therapeutically challenging because both interventional and drug therapies often are ineffective. OBJECTIVES To determine if pelvic pain can be treated effectively with compounded topical amitriptyline-ketamine. STUDY DESIGN A retrospective review of m...

A 32-year-old female, with a history of secondarily-generalized convulsive epilepsy, mental retardation, and a psychiatric illness, developed neuroleptic malignant syndrome while receiving carbamazepine and amitriptyline concurrently. We hypothesize that the addition of amitriptyline to carbamazepine caused a decrease in the serum level of carbamazepine, resulting in NMS. We conclude that combi...

Publishing; 2004. p. 473-86. 5. Caksen H, Akbayram S, Odabaş D, Ozbek H, Erol M, Akgün C, et al. Acute amitriptyline intoxication: An analysis of 44 children. Hum Exp Toxicol 2006;25:107-10. 6. Wohlreich MM, Welch W. Amitriptyline abuse presenting as acute toxicity. Psychosomatics 1993;34:191-3. 7. Prahlow JA, Landrum JE. Amitriptyline abuse and misuse. Am J Forensic Med Pathol 2005;26:86-8. 8....

The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects. Sodium bicarbonate had a variable effect on the lowered RET. The toxic arrhythmo...

Aim: To compare the efficacy of amitriptyline, pregabalin and placebo in alleviating pain associated with diabetic peripheral neuropathy. Method: A total of 150 patients were randomly recruited for the study. Assessment for pain relief was carried out on an 11-point, Likert-like numeric rating scale [NRS]; 0= no pain” to 10=worst possible pain”) over a 7-day baseline period. Following a 1-week ...