نتایج جستجو برای: amitriptyline

تعداد نتایج: 1557  

Journal: :medical journal of islamic republic of iran 0
hamid reza jamsiddi from the department of pharmacology, isfahan university of medical sciences, isfahan, islamic republic of iran. taghi ghafghazi

the antiulcer effects of different tricyclic antidepressants (trimipramine, doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. acute gastric ulcer was induced by oral administration of o. 6n hcl solution, 1 ml/rat. pretreatment of animals with doxepin, trimipramine, amitriptyline, im...

Journal: :iranian journal of pharmaceutical research 0
ehsan fattahian department of pharmacology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran valiollah hajhashemi department of pharmacology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran mohammad rabbani department of pharmacology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran mohsen minaiyan department of pharmacology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran parvin mahzouni department of clinical pathology, school of medicine, isfahan university of medical sciences, isfahan, iran

depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. th...

Because of less systemic side effects of topical medications in pain relief of the painful form of diabetic peripheral neuropathy, this study aimed to compare the effect of amitriptyline and capsaicin cream in relieving pain in this condition. In this randomized, double-blind and non -inferiority trial, 102 patients received amitriptyline 2% and capsaicin 0.75% creams  3 times a day for 12 week...

Journal: :Chemistry & biology 2009
Sung-Wuk Jang Xia Liu Chi-Bun Chan David Weinshenker Randy A Hall Ge Xiao Keqiang Ye

Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation. Amitriptyline, but not any other tricyclic or selective serotonin reuptake inhibitor antidepressants, promotes TrkA auto...

Journal: :Anesthesiology 2009
Yueh-Hua Tai Ru-Yin Tsai Shinn-Long Lin Chun-Chang Yeh Jhi-Joung Wang Pao-Luh Tao Chih-Shung Wong

BACKGROUND This study explores the underlying mechanism of the antiinflammatory effect of amitriptyline in chronic morphine-infused rats. METHODS Male Wistar rats were implanted with two intrathecal catheters. One catheter was for the continuous infusion of saline, amitriptyline (15 microg/h), morphine (15 microg/h), p38 mitogen-activated protein kinase inhibitor SB203580 (0.5 microg/h), morp...

Journal: :Balkan medical journal 2016
Nil Hocaoğlu Nergis Murat Serap Cilaker Mıcılı Burç Aydın Bekir Uğur Ergür Şule Kalkan

BACKGROUND Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. AIMS To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. STUDY DESIGN Animal experimentation, isolated ...

2010
Valiollah Hajhashemi Hossein Sadeghi Mohsen Minaiyan Ahmad Movahedian Ardeshir Talebi

OBJECTIVE The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. METHODS First, amitriptyline was administered intraperitoneally (i.p.) at doses of 20, 40 and 80 mg kg-1, 30 min before subplantar injection of carrageenan. Second, amitriptyline was given intracerebroventriculary or intra...

Journal: :Rheumatology 2008
B Nishishinya G Urrútia B Walitt A Rodriguez X Bonfill C Alegre G Darko

The objective of this study was to assess the efficacy and safety of amitriptyline as a treatment of FM. A comprehensive computerized search in Medline (Pubmed), EMBASE and The Cochrane Library was performed. Randomized controlled trials (RCTs) comparing amitriptyline vs placebo in adult patients suffering from FM were identified, the methodological quality was assessed and the results of the m...

Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antidepressants such as amitriptyline has been reported. Acetic acid colitis was induced in both reserpinised (depressed) and non-reserpinised (normal) rats. Reserpinised groups received reserpine (6 mg/kg, i.p.) one hour prior to colitis induction. Th...

A novel electrochemical sensor was proposed for the determination of amitriptyline based on the copper oxide (CuO) nanoparticles modified graphite screen-printed electrode. CuO nanoparticles were used to enhance the surface area of the electrode and then improve the sensitivity of the electrochemical sensor. Amitriptyline electrochemical response characteristics of the modified electrode in a p...

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