I)evelopment and Loss of Tolerance to Morphine in the Rat after Single and Multiple Injections. JOSEPH COCHIN AND CONAN KORNETSKY 1 The Importance of Steric Configuration in Certain Morphinemimetic Actions of Synthetic Analgetics. ROBERT M. \EATCH, TERRINE K. ADLER AND E. LEONG WAY 11 The Influence of Morphine on Glucose Utilization in Cerebral Preparations of Rats. A. E. TAKEMORI 20 Comparison...

IN THE treatment of barbiturate poisoning the therapeutic emphasis has shifted from the use of analeptics and efforts at arousal to a regimen of physiologic supportive therapy.1 For some time, though, analeptics were drugs of choice, the results being transferred from experimental evidenceQ* 3 despite some reports49 5 about the ineffectiveness of these drugs in animals given large doses of barb...

The interaction of pentobarbitone sodium with three analeptics viz. micoren, pentylenetetrazol and methedrine was studied in mice. Micoren prolonged pentobarbitone sleeping time. pentylenetetrazol shortened the sleeping time. Methedrine also shortened the sleeping time, but clonic convulsions of mild to severe intensity were noticed 45-60 minutes after the drug injection.