background: regarding the strong differentiation and anti-leukemic activity of dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. the aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using u937 cells. met...

background: molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. the aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (mcf-7). the pattern of cell death in mcf-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

Age-related macular degeneration (AMD) is related to central visual loss in elderly people and, based on the increment percentage of aging population, number suffering from AMD could increase. initiated by retinal pigment epithelium (RPE) cell death, finally leading neovascularization macula lutea. an uncurable disease, but symptom can be suppressed. The current therapy classified into four typ...

The therapeutic effect of combined drugs on cervical cancer has been confirmed. Whether antiprogrammed cell death protein 1 antibody with paclitaxel mediates the phosphoinositide 3-kinase-protein kinase B pathway to regulate still needs further research. 20 nude mice received subcutaneous administration Henrietta Lacks cells establish model which was then assigned into blank control group, grou...

Cardiosphere-derived cells (CDCs) have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are required for the regenerative effects of human CDCs and mimic the cardioprotective benefits of CDCs such as anti-apoptotic effect in animal myocardial infarction (MI) models. Here we aimed to investigate the anti-apoptotic effect of the hypoxic and normoxic...

Background: Due to high mortality of patients with metastatic breast cancer and limited strategies for management this malignancy, development novel therapeutic approaches anti-cancer agents is essential. Objectives: In the present study, we investigated in vitro anti-proliferative effects hydroxytyrosol, as a natural chemotherapeutic agent, against cells MDA-MB-231 MCF-7. Methods: The anti-pro...

Background: Cell viability and apoptosis are two crucial factors that may determine cell fate. There are several factors, such as hypoxia, which may be effective in cell processes. Because of its unique features, such as its antioxidant, anti-inflammatory, and anti-apoptosis mechanisms, kohlrabi (Brassica oleracea var. gongylodes) extract may be used in the amelioration of cell viability and a ...

in many acute leukemias, normal differentiation does not occur. however, in many cell lines derived from hematologic malignancies, differentiation or apoptosis can be induced by variety of agents. despite advances in the treatment of acute lymphoblastic leukemia (all), in most patients long-term survival rates remain unsatisfactory, especially in t-cell derived all. thus we studied the anti-can...

Objective(s): T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor. Administration of chemical compounds influencing apoptosis and T cell development has been discussed as promising novel therapeutic strategies. Valproic acid (VPA) as a recently emerged anti-neoplastic histone deacetylase (HDAC) inhibitor and pioglitazone (PGZ) as a high-affinity peroxisome p...