is a mucosal commensal organism in normal individuals, but Candida albicans is a major pathogen causing systemic and mucosal infections in immunocompromised individuals. Azoles have been very effective anti-fungal agents and the mainstay in treating opportunistic mold and yeast infections. Azole resistant strains have emerged compromising the utility of this class of drugs. It has been shown th...

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose medicinal products. With centuries had emerged as a magnanimous field science getting facelift from available natural compounds synthesis newer complex molecules possessing activity while transit earth synthetically furnished laboratory. Medicinal or pharmaceutical discipline at inters...

methanolic and aqueous extracts of dendrophthoe falcata linn. leaves which belongs to the loranthaceae family, were evaluated through dpph (1, 1-diphenyl -2-picryl-hydrazyl), antilipid peroxidation and nitric oxide scavenging methods to assess the antioxidant activity. methanolic and aqueous extracts of dendrophthoe falcata leaves were also evaluated for their anti-inflammatory activity by carr...

leptadenia reticulata was reported to be used for several medicinal purposes. the present study was undertaken to evaluate anti-inflammatory, analgesic and lipid peroxidation inhibition activities of l. reticulata. the anti-inflammatory assay was performed by λ-carrageenan and formalin induced paw edema test. pro inflammatory mediators (il2, il6, tnf-α) in serum of treated and control organism ...

Background and Objective: Dermatophytosis is a superficial fungal disease. Prosopis farcta has attracted attention for ethnobotany and medical purposes. The present study aimed to investigate the antifungal properties of Prosopis farcta extracts against Trichophyton mentagrophytes (PTCC 5054) and five archived terbinafine resistant clinical isolates of T. mentagrophyte, based on an ethnobotanic...

Nigella sativa (N. sativa) grows in various parts of the world, particularly in Iran. It has been traditionally used as a folk remedy to treat a number of diseases. The seeds of this plant contain moisture, proteins, carbohydrates, crude fiber, alkaloids, saponins, ash, fixed oils and essential oil. The major components of the essential oil are thymoquinone, p-cymene, trans-anethole, 2-methyl-5...

Echinoderms are independent and quite special branch of world animals. Sea cucumbers are among the strangest members of echinoderm class regarding their structure and physiology. These fauna have been tested with regard to anti-bacterial, anti-fungal, anti-coagulants, anti-virus, cytotoxic, hemolytic and anti-HIV features. In this study, the antibacterial activity of Holothuria leucospilota...

Cryptococcus neoformans is an opportunistic pulmonary fungal pathogen that disseminates to the CNS causing fatal meningitis in immunocompromised patients. Dendritic cells (DCs) phagocytose C. neoformans following inhalation. Following uptake, cryptococci translocate to the DC lysosomal compartment and are killed by oxidative and non-oxidative mechanisms. DC lysosomal extracts kill cryptococci i...

New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinon...