The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is pivotal to the cellular anti-oxidative defence strategies in most organisms. Although its production mediated by different enzyme systems has been relatively well-studied, metabolic networks dedicated to the biogenesis of NADPH have not been fully characterized. In this report, a metabolic pathway that promotes the conversion of...

To explore how screening for potential nutrient bio-activity could be improved by integrating biological and chemical markers of cellular responses, we assessed the effect of the known anti-oxidants, catechin and chlorogenic acid, on anti-oxidant activity in vitro. We determined an active concentration (25 μM) of each compound and then measured its effects on anti-oxidant gene expression and re...

The anti-oxidant properties of vitamin C and phenolic compounds citrus fruits are well established. However, the evaluation anti-inflammatory antithrombotic potential both more amphiphilic lipophilic components needs further attention. In this study, freshly squeezed juices their lipid bioactives from Navalina Sanguine orange varieties Clementine variety mandarins, as remaining by-products, wer...

OBJECTIVE/AIM A new group of autoantibodies in Rheumatoid Arthritis (RA), the anti-cyclic citrullinated peptide (anti-CCP) antibodies directed to citrulline-containing proteins, which are of value for the severity of RA. Up to date, the relationship between anti-CCP antibodies and oxidant, anti-oxidant activity in patients with RA has not been elucidated in the previous studies. In this study w...

BACKGROUND Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated enzymatic antioxidant system. Besides, the mitochondrial DNA (mtDNA) haplogroups are associated with the OA disease. Thus, the main goal of this work is to assess the incidence of the mtDNA ha...

BACKGROUND Oxidative stress is recognized to be one of predisposing factor in the pathogenesis of COPD. The oxidant/antioxidant imbalance is significantly pronounced in patients with COPD exacerbation. N-acetylcysteine (NAC) seems to be able to reduce COPD exacerbations by modulating the oxidative stress in addition to its well-known mucolytic activity, but there are discordant findings on the ...

Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism, mainly through the mitochondria and peroxisomes, but their release is enhanced by the activation of oxidant enzymes such as NADPH oxidases or downregulation of endogenous antioxidant enzymes such as manganese-superoxide dismutase (MnSOD) and catalase. Transforming growth factor-β (TGF-β), found to be overexpr...

The anti-oxidant activities for a diverse set of flavonoids as TEAC (Trolox equivalent anti-oxidant capacity), assay were subjected to 3D-QSAR (3 dimensional quantitative structural-activity relationship) studies using CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indices analysis). The obtained results indicated superiority of CoMSIA model over CoMFA...

17 Obstructive sleep apnea (OSA) is one of the most common causes of hypertension 18 in western societies. OSA causes chronic intermittent hypoxia (CIH) in specialized O 2-19 sensing glomus cells of the carotid body. CIH generates increased reactive oxygen 20 species (ROS) that trigger a feed-forward mechanism in which increased intracellular 21 calcium levels ([Ca 2+ ] i) trigger increased HIF...

Liver fibrosis is a global health problem and its relationship with imidazoline I2 receptor has not been reported. This study aimed to investigate the effects and underlying mechanisms of imidazoline I2 receptor (I2R) inhibitor idazoxan (IDA) on carbon tetrachloride (CCl4)-induced liver fibrosis. In vivo liver fibrosis in mice was induced by intraperitoneally injections of CCl4 for eight weeks,...