background: immune system disturbances have an important role in endometriosis which may lead to infertility. it seems that inflammatory cytokines specially tumor necrosis factor alpha (tnf-) which were produced by activated macrophages have an important role in pathology of endometriosis. based on this theory, anti tnf- drugs like pentoxifylline (px) are suggested as new drugs for endometrio...

background: periodontitis and rheumatoid arthritis (ra) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (tnf-α)-induced bone resorption that is involved in the pathogenesis of both. objectives: to investigate the effect of tnf-α blockade on periodontal conditions in patients with active ra. method: the periodontal statuses of 3...

introduction: the systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. this study was purposed to verify the roles of synovial tnf-α, il-6 and fractalkine (fkn) in edema changes during different stages of complete freund’s adjuvant (cfa)-induced knee arthritis in rats. methods: 168 male wistar rats were divided in 7 groups a...

Introduction: The systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. This study was purposed to verify the roles of synovial TNF-α, IL-6 and fractalkine (Fkn) in edema changes during different stages of Complete Freund’s Adjuvant (CFA)-induced knee arthritis in rats. Methods: 168 male Wistar rats were divided i...

Background: According to previous studies, the effectiveness of interleukin-17 (IL-17) inhibitors was higher in anti-TNF-naïve patients with ankylosing spondylitis (AS) [1,2]. Netakimab (NTK) is a humanized anti-IL-17A antibody approved for treatment AS, psoriatic arthritis, moderate-to-severe plaque psoriasis Russia and Belarus. Objectives: To compare efficacy NTK anti-TNF-experienced active A...

Introduction/Objective. The aim of our study was to retrospectively analyze data about efficacy and persistence on different anti-TNF? treatment in spondyloarthritis (SpA). Methods. We analyzed SpA patients whose were entered into the Serbian national registry. All divided two groups: non-switcher (patients who treated with one anti-TNF?) switcher group (who has switched from first second third...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...