this prospective case-control study was carried out to evaluate the Prevalence of positive cases of anti-HCV Ab in 107 thalassemic patients  and 107 children without any previous history of blood transfusion as a control group.ELISA GENERATION II was used for serologic investigation and then positive cases were confiemed  by RIBA generation I.the average age of thalassemic patients was 9.2+_4.3...

introduction : regular blood transfusions for patients with thalassemia major have improved their overall survival, but carry a definite risk of being infected with blood born viruses especially hepatitis b and c. nowadays, it has remained as main health concern about these patients. in this study, we tried to define the prevalence rate of hepatitis b and c and survey the related risk factors a...

Introduction: Intravenous drug users as a serious health problem in communities have economical and social effects as well as health and hygienic complications. Viral infections may be transmitted through drug injection by shared syringes among users. The aim of this study has been to determine the relative frequency of HBV, HCV and HIV infection’s markers as epidemiological data in Ahvaz. Ma...

To evaluate whether a new enzyme immunoassay developed for the simultaneous detection of hepatitis C virus (HCV) core antigen (Ag) and anti-HCV antibodies (anti-HCV Ab) (Monolisa HCV Ag/Ab ULTRA; Bio-Rad) could improve the early detection of HCV infection, we compared its sensitivity to that of anti-HCV, HCV core Ag, and HCV RNA assays. The populations studied included 12 blood donor samples po...

results among the 181 anti-hcv ab negative patients, 13 (7.2%) were positive for hcv core ag and 11 (6%) had detectable hcv rna with a range of 40-336543 iu/ml by pcr. the two tests had a high measurement agreement (kappa=0.82, p<0.001). of the 13 patients with positive hcv core ag test results, 3 were negative for hcv rna. considering real time pcr for hcv rna as the gold standard for hcv infe...

results a total of 52 (17.8%) cases, including 45 (7.7%) controls in group 1 (1st degree relatives) and 50 (8.6%) controls in group 2 (non-hematological malignancy), showed positive results for anti-hcv abs and had a odds ratio value of 2.59 (95% ci: 1.69-3.97) for group 1 and 2.31 (95% ci: 1.52-3.50) for group 2 (p value of 0.000 for both groups). nhl patients who showed positive results for a...

background viral hepatitis is a systemic infection affecting the liver predominantly. almost all cases of acute viral hepatitis are caused by one of five viral agents: hav, hbv, hcv, hdv and hev. the present study aimed to find out the frequency of various forms of viral hepatitis (hav, hbv, and hcv), route of transmission, the history of vaccination against hepatitis b, and clinical findings i...

BACKGROUND End-stage renal disease patients on chronic hemodialysis are among high risk groups for hepatitis C virus (HCV) infection for whom routine HCV screening is recommended. Anti-HCV antibody (ab) testing may not be reliable to detect all infected cases because of the blunted ab response due to depressed immune state in these patients. Using a more reliable, cost-effective and non-complex...