in this research, dried acetone:chloroform extract of aerial parts of e. denticulata as one of the endemic plants to iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23z-ene-3β,25-diol, cycloart-23z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. the stru...

Inhibitors of cell enzyme Inosine 5 ́-Monophosphate (IMP) dehydrogenase – Ribavirine (Rbv), Micophenolic acid (MPA) and Mizoribine (MZR) have potential application as antiherpes agents in combination with acyclovir (ACV). The effectivity of action of ACV on herpesvirus replication is improved after decreasing of the concentration of dGTP as a result of IMP dehydrogenase inhibition. The antiviral...

A new compound, 9-(3,4-dihydroxybutyl)guanine, has been synthesized and its antiherpes activity determined. 9-(3,4-Dihydroxybutyl)guanine was selectively phosphorylated by herpes simplex virus thymidine kinase and had a high affinity for this enzyme, with an inhibition constant of 1.5 microM. In cell culture, replication of different strains of herpes simplex virus types 1 and 2 was inhibited t...

PURPOSE To report uveitis secondary to ocular penetration of caterpillar hairs (setae). METHODS Case report. A documented attack of acute anterior uveitis was caused by initially overlooked penetration of caterpillar setae. RESULTS A 66-year-old man presenting with unilateral hypertensive keratouveitis was treated with antiherpes simplex medication (along with local anti-inflammatory and cy...

The Herpesviruses are important human pathogens that can cause mild to severe lifelong infections with high morbidity. Moreover, Herpes simplex virus type 2 (HSV-2) has been reported to be responsible for increased transmission of human immunodeficiency virus (HIV) and progression of AIDS. Therefore, the discovery of novel anti-herpesvirus drugs deserves great efforts. Ethnomedicines have been ...

(E)-5-(2-Bromovinyl)-2'-deoxyuridine (bromovinyldeoxyuridine) was found to suppress the development of herpetic skin lesions and the paralysis and mortality associated therewith in hairless mice inoculated intracutaneously with herpes simplex virus type 1. This protective effect was achieved with bromovinyldeoxyuridine applied topically at 1, 3, or 10% in either dimethylsulfoxide (DMSO), Beeler...

During the 18 months January 1975 to June 1976, 25 cases of acute herpetic follicular conjunctivitis and keratoconjunctivitis resembling adenovirus ocular infection presented in the External Eye Disease Clinic, Moorfields Eye Hospital, City Road, London. Herpes simplex virus was isolated in HEp2 cells in 22 patients, and the remaining 3 patients were identified by a minimum 4-fold rise in the l...

(E)-5-(2-Bromovinyl)-2'-deoxyuridine is a potent antiherpes compound with far better activity against herpes simplex virus type 1 than type 2. To understand the role of drug metabolism in this differential antiviral activity, we examined the metabolic fate of this drug in virus-infected and mock-infected Vero cells by high-pressure liquid chromatography. After 8 h of incubation in which cells w...