The endocannabinoid anandamide (AEA) is an antinociceptive lipid that is inactivated through cellular uptake and subsequent catabolism by fatty acid amide hydrolase (FAAH). Fatty acid binding proteins (FABPs) are intracellular carriers that deliver AEA and related N-acylethanolamines (NAEs) to FAAH for hydrolysis. The mammalian brain expresses three FABP subtypes: FABP3, FABP5, and FABP7. Recen...

FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist. Recently it was also shown that FTY720 can reduce prostaglandin synthesis through the direct inhibition of the cytosolic phospholipase A2 (cPLA2). Since prostaglandins are important mediators of nocicepti...

Opioid type of analgesics open ATP sensitive potassium channel at the cellular level to produce antinociceptive response. These channels have also been shown to modulate insulin secretion by the pancreas. 7-hydroxy flavone, an antinociceptive agent shown to act through opioid pathways was investigated for its effect on glycaemic state and associated algesic state. The involvement of ATP sensiti...

Amelioration of neuropathic spinal cord injury (SCI) pain is a clinical challenge. Increasing the endocannabinoid anandamide and other fatty acid amides (FAA) by blocking fatty acid amide hydrolase (FAAH) has been shown to be antinociceptive in a number of animal models of chronic pain. However, an antinociceptive effect of blocking FAAH has yet to be demonstrated in a rat model of neuropathic ...

The amygdaloid complex is a prominent temporal lobe region that is associated with "emotional" information processing. Studies in the rodent have also recently implicated the amygdala in the processing and modulation of pain sensation, the experience of which involves a considerable emotional component in humans. In the present study, we sought to establish the relevance of the amygdala to pain...

BACKGROUND In particular surgical conditions, a balanced anesthesia with a high-antinociceptive contribution is required. This may induce cardiovascular impairment and thus compromise tissue oxygenation. In this prospective observational study, we investigated the hemodynamic stability and tissue oxygen saturation (StO2) in 40 patients with a high-antinociceptive general anesthesia, goal-direct...

The aim of this study was to evaluate the antinociceptive and sedative effects of midazolam and diazepam in 10 Thoroughbred mares. The sedative effects of midazolam (0.05, 0.1 and 0.15 mg/kg iv) and diazepam (0.05, 0.15 and 0.25mg/kg iv) were investigated by determination of the spontaneous locomotor activity (SLA) in automated behavior stalls and by measuring the head ptosis (HP). The antinoci...

Leonurus cardiaca, commonly known as motherwort, is a member of the Lamiaceae family. It has a number of interesting biological activities, for example, sedative and hypotensive, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of the present study was to investigate the effect of alcoholic extract of aerial part of Leonurus cardiaca on nociceptive response using formalin, ...

The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Mitragyna parvifolia (MPEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum antiinflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and t...

The antinociceptive activity of mycelial extract from fermented mushroom of Ganoderma lucidum Coprinus comatus and Grifola frondosa were studied in this paper. The writhing test, formalin test and hot-plate test were used to evaluate the antinociceptive activity of the acetone extracts of the three Species of Fungi of Basidiomycetes in the study respectively. The extract of Ganoderma lucidum in...