b-carboline alkaloids such as harmaline and nicotine are naturally present in the human food chain. plants which contain b-caroline have anxiety and hallucinogenic effects. in this study the change in like – anxiety behaviors was investigated after intra- amygdala injections of nicotine and harmaline and intra action of them in male rat. different doses of harmaline, nicotine and its compounds ...

the mesolimbic dopamine (da) system contains both d1-like and d2-like receptors, has been connected to control of locomotor behavior. an apparent role for d1 and d2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. the nucleus accumbens (nac) is comprised of a core and a shell subregion, which is a component of t...

introduction: in this study, we investigated the role of n-methyl-d-aspartate (nmda) receptors in the ventral hippocampus (vh) and their possible interactions with gabaa system on anxiety-like behaviors. methods: we used an elevated-plus maze test (epm) to assess anxiety-like behaviors and locomotor activity in male wistar rats. results: the results showed that intra-vh infusions of different d...

The mesolimbic dopamine (DA) system contains both D1-like and D2-like receptors, has been connected to control of locomotor behavior. An apparent role for D1 and D2 receptors throughout the mesolimbic system in the alteration of locomotor behavior has been demonstrated in pharmacological studies. The nucleus accumbens (NAc) is comprised of a core and a shell subregion, which is a component of t...

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/da...

we studied the effect of the selective alha-2 adrenoceptor blocker idazoxan and precursor serotonin (5-htp) on anxiety-related behavior in rats. the conflict drinking test, and evaluator plus-maze were used as model. idazoxan (2 mg/kg) showed an anticonflict effect, having doses dependently increased the number of punished lickes. 5-htp showed that anxiolytic-like effect in both models. this dr...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

introduction: our previous study has showed that chronic administration of magnesium oxide nanoparticles (mgo np) can reduce anxiety in adult male rat. in this study the effects of mgo np on anxiety induced by morphine withdrawal were investigated in adult male mice. methods: adult male nmri mice (weighing 27 ± 3 g) divided into groups: control, receiving intraperitoneal (i.p.) injection of mgo...