BACKGROUND AND AIM Aphthous stomatitis is one of the adverse effects associated with interferon (IFN) that forces dose reduction of IFN and there is no established therapy. This study was aimed to investigate whether irsogladine maleate, which enhances the functions of intercellular communication through the gap junctions, is effective for the treatment of aphthous stomatitis developed in hepat...

Recurrent aphthous stomatitis is a common disease of the oral mucous membranes. Currently a hypothesis is being discussed that it might be pathogenetically related to coeliac disease. We evaluated the frequency of coeliac disease anti-endomysial (or anti-transglutaminase) antibodies in patients with recurrent aphthous stomatitis. Blood samples from 42 patients were evaluated and 2/42 (4.7%) wer...

background: recurrent aphthous stomatitis (ras) is the most common painful ulcers of oral mucosal which can cause many sufferings. treatment of ras often includes administration of corticosteroids, analgesics and regulators of the immune system. however, considering the side effects of these medications, even their topical application must be done with caution. alum is used in traditional medic...

Recurrent aphthous stomatitis consists on recurring oral ulcers of unknown etiology. Oral ulcers may be different in number and size depending on the clinical presentation, which also determines the time needed for healing. Moreover, there are factors associated to outbreaks but not implicated in its etiopathogenesis. When oral aphthosis has a known etiology, it is not considered as recurrent a...

Microbial factors may play a role in the pathogenesis of recurrent aphthous stomatitis (RAS). Because of similarities in the characteristics of peptic ulcers and oral aphthous ulcers, it seems reasonable to hypothesize that Helicobacter pylori (H. pylori) could play a role in the development of RAS. The aim of the present study was to determine the relationship between H. pylori and RAS using t...

UNLABELLED Recurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according ...

J Dent Health Oral Disord Ther 2016, 5(5): 00170 Abbreviations: CREST: Calcinosis Raynaud Phenomenon Esophageal Dismotility Sclerodactyly Teleangiectasia; GERD: Gastro Esophageal Reflux Disease; CD: Celiac Disease; RAS: Recurrent Aphthous Stomatitis; MiRAS: Mikulicz’s Aphthae; MaRAS: Sutton’s Aphthae; HeRAS: Herpetiform Aphthae; PFAPA: Periodic Fever Aphthous Stomatitis Pharyngitis and Adenitis...

IL: interleukin RAS: recurrent aphthous stomatitis OBSERVATION Recurrent aphthous stomatitis (RAS) is a common cause of recurrent oral ulcers, which often leads to significant impairment of a patient’s quality of life. The underlying pathogenic mechanism remains unclear, and no treatment modality is uniformly effective. In this report, we describe the use of apremilast, an oral phosphodiesteras...

background: oral aphthous is one of the most common oral mucosal inflammatory disorders which are very painful. there is no definite medical strategy up to now for aphthous treatment. recently, some researchers have focused on immunomodulatory drugs such as tacrolimus and pimecrolimus in preventing aphthus recurrences. the aim of this study is to assess the effect of pimecrolimus cream against ...