Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...

Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population wa...

Using a benchmark Ames mutagenicity data set, we evaluated the performance of molecular fingerprints as descriptors for developing quantitative structure-activity relationship (QSAR) models and defining applicability domains with two machine-learning methods: random forest (RF) and variable nearest neighbor (v-NN). The two methods focus on complementary aspects of chemical mutagenicity and use ...

time limitation is one of the legal institutions of the domestic law. this institution is more welcomed in the civil law system compared to the common law. immunity, amnesty and time limitation are the most important obstacles in the ending of impunity culture. immunity is a international phenomenon, whereas amnesty and time limitation are considered as domestic elements. international criminal...

The present work proposes a unified conceptual framework to describe and quantify the important issue of the Applicability Domains (AD) of Quantitative Structure-Activity Relationships (QSARs). AD models are conceived as meta-models micromicro designed to associate an untrustworthiness score to any molecule M subject to property prediction by a QSAR model micro. Untrustworthiness scores or "AD ...

Cytochromes P450 (CYP) are a superfamily of enzymes, involved in metabolism of xenobiotic compounds. CYP are involved in metabolism of a large amount of drugs, currently present on the market. Therefore, prediction of CYP inhibition activity of small molecules poses an important task, especially in early stage drug discovery, due to high risk of drug-drug interactions. It is estimated that CYP ...