A well known anti-cancer lignan arctiin has not been studied for its antibacterial activity based on our literature search. In the present work, the antibacterial and general toxicity of the arctiin from the seeds of Centaurea sclerolepis is studied. Arctiin did not show any significant antibacterial activity against both Gram-positive and Gram-negative bacteria when compared with the positive ...

Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties in animal models. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. However, the growth inhibitory mechanism of arctiin remains unknown. Herein we report that arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in...

The pharmacokinetic profile of arctiin, the major active lignan in fruits of Arctium lappa L., was investigated. Its main meta"bolite arctigenin was identified by an LC-MS method, and an HPLC-UV technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. Chromatographic separation was performed on an Agilent™ C₁₈ HPLC column with acetonitrile ...

BACKGROUND/OBJECTIVES The purpose of this study was to examine the effects and associated mechanisms of arctiin, a lignan compound found in burdock, on adipogenesis in 3T3-L1 cells. Also, the effects of arctiin supplementation in obese mice fed a high-fat diet on adiposity were examined. MATERIALS/METHODS 3T3-L1 cells were treated with arctiin (12.5 to 100 µM) during differentiation for 8 day...

Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the rele...

Ultrasound-assisted extraction is evaluated as a simpler and more effective alternative to conventional extraction methods for the extraction of bioactive compounds from natural product. This study investigated the use of ultrasound-assisted extraction to extract three dibenzylbutyrolactone lignans, including tracheloside, hemislienoside, and arctiin from Hemistepta lyrata. Factors such as extr...

tone, were reported from human and animal species. They were given the name mammalian lignans, because unlike plant lignans they carry phenolic hydroxy groups only in the meta position of the aromatic ring and they were assumed to play an important role in the prevention of hormone-dependent diseases, such as breast cancer and prostate cancer. The origins of enterodiol and enterolactone were la...

Background and objectives: Burdock (Arcticum lappa L.) is a Eurasian species of plants in the sunflower family and has been used for hundreds of years by scientists and traditionally in North America, Europe, Asia and especially in China. It has also been used in gouts, hepatitis, blood pressure and other inflammatory disorders. There are several major compounds in dif...

Background and objectives: The genus Centaurea from the Asteraceae family is one of the most widely distributed plant genera worldwide that has been extensively used in folk medicine for hundreds of years. The present study is the first investigation about the principal constituents of Centaurea albonitens Turrill which is native to Iran. Methods: The aerial parts of C. albonitens were extracte...