results in this case, the protoscolicidal effect of artemether and its combinations was significantly (p < 0.05) higher than other groups; the maximum protoscolicidal effect was found with 200 μg/ml of artemether after 4 days whereas albendazole killed protoscoleces on the 7th day post-incubation. surprisingly, the incubation of protoscoleces with artemisinine exhibited promising results, as on...

Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the surveillance and the containment of Plasmodium falciparum resistant strains. We investigated resistance to artemisinin-based combination therapies currently in use in Democratic Republic of Congo...

Cerebral malaria is the most important manifestation of severe Plasmodium falciparum infection. The clinical picture in South East Asian adults differs from that in African children. The children are more likely to have abnormal brain stem reflexes, signs suggestive of cerebral herniation, and raised CSF opening pressure, and to suffer persistent neurological sequelae. The mortality remains hig...

Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million people, mainly small children in Africa. The highly efficacious artemisinine combination therapy is being launched globally, constituting the main hope for fighting the disease. Amodiaquine is a main partner in these combinations. Amodiaquine is almost entirely metabolized by the polymorphic cytochrom...

The rise of artemisinin resistant Plasmodium falciparum along the Thai-Cambodian border is an urgent public health threat. We conducted an employer-based survey of migrant workers in two provinces in Thailand along the Thai-Cambodian border to explore socio-economic conditions, bednet ownership, and parasite prevalence among migrant workers. Five thousand three hundred seventy-one migrant worke...

Tido von Schoen-Angerer and colleagues discuss the new Affordable Medicines Facility for malaria (AMFm), which subsidizes and facilitates access to artemisinin-based combination therapy, and what mechanisms are needed to ensure it stays focused on quality patient care.

There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patient...