Otsuka, Eri, Akira Yamaguchi, Shigehisa Hirose, and Hiromi Hagiwara. Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. Am. J. Physiol. 277 (Cell Physiol. 46): C132–C138, 1999.—The stromal cell line ST2, derived from mouse bone marrow, differentiated into osteoblast-like cells in response to ascorbic acid. Ascorbic acid induced alkaline p...

It has been suggested that ascorbic acid is necessary for the transparency and metabolism of the crystalline lens (see Bellows, 1944). Primarily, this is based on well-authenticated observations of a loss of ascorbic acid from animal and human lenses undergoing spontaneous opacification. In experimentally induced cataract, however, loss of ascorbic acid does not always occur; thus, naphthalene ...

Studies were conducted to evaluate the blood levels of ascorbic acid, dehydroascorbic acid, glutathione, and histamine in patients with gastric carcinoma, tuberculous enteritis and non-specific ulcerative colitis. Leucocyte ascorbic acid, urinary excretion of total ascorbic acid and ascorbic acid saturation test were also carried out in order to assess the ascorbic acid status of these patients...

Introduction: ascorbic acid is a water-soluble vitamin solved in water that acts as a helper of some the enzymes in the reactions of energy metabolism. Thus, the study aims to investigate the use of supplemental ascorbic acid on the aerobic and anaerobic capacity of the children.Methodology: Participants of this quasi-experimental study were 18 children in Esfahan who were randomly selected and...

An attempt was made to unravel further the mechanism by which high dietary concentrations of ascorbic acid influence copper metabolism. The addition of ascorbic acid to the diet of rats caused about a twofold increase in plasma ascorbate concentrations and reduced group mean plasma and tissue concentrations of Cu. The effect of 10 g ascorbic acid/kg diet was greater than that of 1 g/kg. Ascorbi...

Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs’ effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid. Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypert...

Objective(s): The aim of this study was to determine the protective role of ascorbic acid on apoptosis and proliferation of spermatogonia and primary spermatocyte cells after malathion administration as an organophosphate pesticide in rat testis.Materials and Methods: Thirty male Wistar rats were randomly divided into five groups of 6 ra...

Administration of nicotine leads to incentive and behavioral tolerance in human and animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effects of ascorbic acid administration on the expression and development of nicotine-induced behavioral tolerance in female Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.5 m...

     Osteoporosis is a silent epidemy of today's world, and is also a prevalent problem of health in Iran. The role of nutrients such as ascorbic acid, a key antioxidant vitamin, in this disease has recently attracted researchers' attention. In this study, we studied the relation between plasma ascorbic acid concentration and bone mineral density (BMD) in women referring to Jami clinic, Tehran,...