Background: The enzyme tyrosinase is a copper-containing polyphenol oxidase, which is involved in melanogenesis. It catalyzes the conversion of tyrosine to melanin pigments in mammals. Tyrosinase plays an important role in enzymatic browning, which causes discoloration and loss economic value of many plant food products. This enzyme is widely distributed in fungi, higher plants and animals. Ob...

objective: tyrosinase as the key enzyme in melanin biosynthesis, involves in determining the color of mammalian skin and hair. a variety of dermatological disorders, come up from an unnecessary level of epidermal pigmentation. plants are low-cost and rich sources of active compounds.  methods: more than seventy native plants collected from the central region of kurdistan province collected. inh...

Objective: Tyrosinase as the key enzyme in melanin biosynthesis, involves in determining the color of mammalian skin and hair. A variety of dermatological disorders, come up from an unnecessary level of epidermal pigmentation. Plants are low-cost and rich sources of active compounds.  Methods: More than seventy native plants collected from the central region of Kurdistan province collected. Inh...

Astragalus mongholicus Bunge has long been used to treat cardiovascular disease in Chinese traditional medicine. However, its mechanisms are not fully understood. In this study, we explored potential mechanisms and protective effects of total flavonoids of Astragalus (TFA) on cardiovascular disease using in vitro experiments and diet-induced atherosclerotic rabbits. We identified six components...

Objective: Tyrosinase as the key enzyme in melanin biosynthesis, involves in determining the color of mammalian skin and hair. A variety of dermatological disorders, come up from an unnecessary level of epidermal pigmentation. Plants are low-cost and rich sources of active compounds.  Methods: More than seventy native plants collected from the central region of Kurdistan province collected. Inh...

OBJECTIVE To evaluate the antioxidant activities of different chemical constituents from Astragalus mongholicus Bunge and their protection against xanthine (XA)/xanthine oxidase (XO)-induced toxicity in PC12 cells. METHODS The compounds of Astragalus mongholicus Bunge were isolated by chromatography and the structures were elucidated on the basis of spectral data interpretation. Their antioxi...

Astragalus roots from Astragalus membranaceus Bunge or Astragalus membranaceus var. mongholicus (Bunge) Hsiao are among the most popular traditional medicinal plants due to their diverse therapeutic uses based on their tonic, antinephritic, immunostimulant, hepatoprotectant, diuretic, antidiabetic, analgesic, expectorant and sedative properties. Currently, the herb is produced or cultivated in ...

The anticonvulsant activity of Astragalus squarrosus total extract was assessed in pentylenetetrazole (PTZ)-induced convulsion in mice, with diazepam as the standard drug, while mechanistic studies were also conducted using flumazenil, a GABA A-benzodiazepine receptor complex site antagonist. The extract produced protection against convulsion at 400 mg/kg, comparable with protection of benzodia...