OBJECTIVE This study investigated whether differences exist in atherogen-induced migratory behaviors and basal antioxidant enzyme capacity of vascular smooth muscle cells (VSMC) from human coronary (CA) and internal mammary (IMA) arteries. METHODS Migration experiments were performed using the Dunn chemotaxis chamber. The prooxidant [NAD(P)H oxidase] and antioxidant [NOS, superoxide dismutase...

background: cardiovascular disease (cvd) is the cause of one third of deaths worldwide and this will progress because of increasing cvd's risk factors. the most basic task of dealing with the epidemic of cvd is primary prevention of risk factors. as atherogenic index of plasma (aip) is a strong marker to predict the risk of atherosclerosis and coronary heart disease, we assessed the correlation...

BACKGROUND/AIMS Oxidized low-density lipoprotein (ox-LDL) is a powerful atherogen. Toll-like receptor 4 (TLR4) has a pathophysiological role in regulating inflammatory responses and atherosclerosis. Mast cells can infiltrate into the atheromatous plaque and secrete various pro-inflammatory cytokines, which significantly amplify the atherogenic processes and promote plaque vulnerability. Small i...

Little is known of the environmental factors that initiate and promote disease. The aryl hydrocarbon receptor (AHR) is a key regulator of xenobiotic metabolism and plays a major role in gene/environment interactions. The AHR has also been demonstrated to carry out critical functions in development and disease. A qualitative investigation into the contribution by the AHR when stimulated to diffe...

Glutathione S-transferase (GST) plays a key role in the detoxification of xenobiotic atherogen generated by smoking. To analyze the effect of GSTM1/T1 gene polymorphisms on the development of smoking-related coronary artery disease (CAD), 775 Korean patients who underwent coronary angiography were enrolled. The subjects were classified by luminal diameter stenosis into group A (>50%), B (20-50%...

Research focus: Identification of incidence of an atherogenic lipoprotein pheno‐ type B in four representative diagnoses of cardiovascular diseases: a) arterial hypertension, b) coronary heart disease, c) lower extremity arterial disease, d) ischemic stroke Research methods: A clinical study included 366 patients with a diagnosis of arterial hypertension (n=107), coronary heart disease (n= 104)...

Coronary artery disease due to atherosclerosis is one of the highest killers today. Cholesterol level reduction by diet or medication would lead to either halting, or decreasing atherosclerosis. We examined whether Licorice root extract can halt atherosclerosis. Fifty male rabbits randomly were divided in five groups. They had gone under normal and high cholesterol (HC) diet for six weeks. One ...

Coronary artery disease due to atherosclerosis is one of the highest killers today. Cholesterol level reduction by diet or medication would lead to either halting, or decreasing atherosclerosis. We examined whether Licorice root extract can halt atherosclerosis. Fifty male rabbits randomly were divided in five groups. They had gone under normal and high cholesterol (HC) diet for six weeks. One ...