Background: Atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. Regulatory T cells (Treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. Quantitative and/or functional alteration of Tregs has been shown to play an atheroprotective role and may al...

helicobacter pylori (h. pylori) is a spiral-shaped gram negative bacterium that naturally colonizes the human gastric epithelium. in recent years, large evidence has come to the literature strongly proposing causal link between h. pylori and extra gastric disorders. cardiovascular system is one of the extra gastric organs that can be affected by h. pylori infection. the first evidence suggestiv...

results saffron extracts markedly (p < 0.05) decreased the serum total cholesterol (tc, 90 ± 9.3), triglyceride (tg, 99 ± 10.5), and low-density lipoprotein cholesterol (ldl-c, 27 ± 1.1) in obese rats, while they increased the serum high-density lipoprotein cholesterol (hdl-c, 68 ± 2.2). the atherosclerosis-index (ldl/hdl, 0.39 ± 0.5), atherogenic index (tc/hdl, 1.32 ± 4.2), and the liver enzym...

an association between chlamydia pneumoniae (c. pneumoniae) and cardiovascular disease has been demonstrated. in this study, we aimed to study this potential relationship in 105 iranian patients. coronary artery specimens from 105 iranian patients undergoing cabg were analyzed by pcr method for c. pneumoniae. serological evaluation for c. pneumoniae igg and igm was performed using elisa. 53 spe...

severe coronary artery disease often coexists with peripheral vascular atherosclerosis. the assessment of the supra-aortic circulation is, therefore, of clinical relevance. we herein describe a case of coronary artery disease treated with surgical revascularization using the internal mammary artery and thereafter the progressive atherosclerotic disease of the native coronary arteries as well as...

background: concerns have been raised about the possibility of a predisposition of kawasaki disease (kd) to abnormal lipid profile after an acute phase of disease, which can predispose them to premature atherosclerosis later in life. we determined the lipid profile of children late after kd, and compared it with controls. methods: this historical cohort was conducted on 32 subjects: 16 children...

objective(s):resveratrol (res) is a polyphenol compound that has been shown a promising cardioprotective effect. however, some reports have yielded conflicting findings. herein, we investigated the anti-atherosclerotic effects of res in apolipoprotein e (apo e)-deficient mice on a high cholesterol diet. materials and methods: firstly, atherosclerosis was induced by feeding a high cholesterol di...

Background and Aims: Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sj&ouml;gren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune sys...