Microbial metabolism of dietary components has been causally linked to cardiovascular disease and atherosclerosis. Now, Wang et al. demonstrate that inhibition of microbial TMA lyases, essential for production of pro-atherogenic trimethylamines, prevents atherosclerosis in vivo.

and Atherosclerosis To the Editor: With great interest we read the study by Sramek et al,1 in which they showed that patients with type 3 von Willebrand disease, characterized by an absence of circulating von Willebrand factor (vWF), were not protected against atherosclerosis. The patients in their study were young (mean age 35 years), whereas clinically relevant atherosclerosis typically occur...

Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid- CETP peptide (TT-CETP) was mixe...

Epidemiological data and interventional studies with hormone replacement therapy suggest that women, at least until menopause, are decreased cardiovascular risk compared to men. Still the molecular mechanisms beyond this difference debated investigation in experimental models of atherosclerosis has been pivotal prove activation estrogen receptor is atheroprotective, despite not enough explain d...

Coronary artery disease is the major cause of premature death among men in industrialized countries, and its pathological basis is atherosclerosis. Hemostatic and rheological variables are associated with both prevalent and incident cardiovascular disease and may be mechanisms through which risk factors such as smoking, hyperlipidemia and infections (including periodontal disease) may promote v...

The article presents data on heart damage in patients with rheumatoid arthritis (RA), features of the development ischemic and non-ischemic disease a significant increase risk adverse cardiovascular events. Patients RA are characterized by an increased developing myocardial infarction, failure, rhythm disturbances, sudden cardiac death, general death. possibility fairly rapid dysfunction from m...

abstract introduction. cardiovascular disease is the most common cause of death in developed counteries and it’s morbidity and mortality is also increasing in asia. hypertension, hyperlipidemia and smoking are majore risk factors of atherosclerosis. in recent years infectious agents such as clamidia pneumoniae, helicobacter pylori and dental flora infections seems to be effective in development...

Available statistics and research reveal that most patients with diabetes die from cardiovascular diseases, mainly due to markedly advanced and untreated atherosclerosis. Although the risk of cardiovascular disease increases additively with the number of conventional risk factors, including diabetes, hypertension and dyslipidemia, these conventional risk factors cannot fully account for the ris...

BACKGROUND Cardiovascular disease caused by atherosclerosis remains a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). We evaluated the potential association of cardiovascular risk factors including asymmetric dimethyl L-arginine (ADMA) and the soluble receptor for advanced glycation end products (sRAGE) with preclinical atherosclerosis in patients undergo...