نتایج جستجو برای: atl granzyme htlv

تعداد نتایج: 10406  

Houshang Rafatpanah Reza Farid Hosseini2 Seyed Hassan Pourseyed

    Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the v...

Journal: :Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2010
Maria de Fátima Paim de Oliveira Maria das Graças Vieira Janeusa Primo Isadora C Siqueira Edgar M Carvalho Lourdes Farré Priscila Lima Fatal Achiléa L Bittencourt

BACKGROUND Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL). OBJECTIVE In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH. STUDY DESIGN Over a period of 33 months, the patients were submitted to three-monthly clini...

2014
Toyotaka Kawamata Nobuhiro Ohno Kota Sato Masayuki Kobayashi Norihide Jo Koichiro Yuji Ryuji Tanosaki Yoshihisa Yamano Arinobu Tojo Kaoru Uchimaru

INTRODUCTION Adult T-cell leukemia/lymphoma (ATL) responds poorly to conventional chemotherapy, but allogeneic stem cell transplantation (allo-SCT) may improve disease prognosis. Herein, we report a female patient with human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (HAM)-like myelopathy following allo-SCT for ATL. CASE REPORT She developed crural paresis 14 months after all...

2010
Hiba El Hajj Marwan El-Sabban Hideki Hasegawa Ghazi Zaatari Julien Ablain Shahrazad T. Saab Anne Janin Rami Mahfouz Rihab Nasr Youmna Kfoury Christophe Nicot Olivier Hermine William Hall Hugues de Thé Ali Bazarbachi

Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult T cell leukemia/lymphoma (ATL), a disease with dismal long-term prognosis. The HTLV-I transactivator, Tax, initiates ATL in transgenic mice. In this study, we demonstrate that an As(2)O(3) and IFN-α combination, known to trigger Tax proteolysis, cures Tax-driven ATL in mice. Unexpectedly, this combination therapy ...

2017
Leila Sawada Yoshiko Nagano Atsuhiko Hasegawa Hikari Kanai Kai Nogami Sayaka Ito Tomoo Sato Yoshihisa Yamano Yuetsu Tanaka Takao Masuda Mari Kannagi

Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Since there are no disease-specific differences among HTLV-1 strains, the etiological mechanisms separating these respective lymphoproliferative and inflammatory diseases are not well understood. In this study, by...

Journal: :Blood 2015
Yuya Nagai Masahiro Kawahara Masakatsu Hishizawa Yayoi Shimazu Noriko Sugino Sumie Fujii Norimitsu Kadowaki Akifumi Takaori-Kondo

Adult T-cell leukemia (ATL) is a peripheral CD4(+) T-cell neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). Despite several investigations using human specimens and mice models, the exact origin of ATL cells remains unclear. Here we provide a new insight into the hierarchical architecture of ATL cells. HTLV-1-infected cells and dominant ATL clones are successfully traced back to C...

Journal: :Modern rheumatology 2015
Kunihiko Umekita Kazumi Umeki Shunichi Miyauchi Shiro Ueno Kazuyoshi Kubo Norio Kusumoto Ichiro Takajo Yasuhiro Nagatomo Akihiko Okayama

Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (ATL), is prevalent in Japan. Many HTLV-1-positive patients with RA are assumed...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Chien-Hung Yeh Marcia Bellon Joanna Pancewicz-Wojtkiewicz Christophe Nicot

Human T-cell leukemia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL), an aggressive lymphoproliferative disease with a dismal prognosis. We have previously described the presence of Notch1 activating mutations and constitutive Notch1 signaling in patients with acute ATL. In this study, we report a high frequency of F-box and WD repeat domain containing 7 (FBXW7)/hCDC4 muta...

Journal: :Cancer research 2015
Yuichi Mitobe Jun-ichirou Yasunaga Rie Furuta Masao Matsuoka

Infection of T cells with human T-cell leukemia virus type-1 (HTLV-1) induces clonal proliferation and is closely associated with the onset of adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. Although Tax expression is frequently suppressed in HTLV-1-infected cells, the accessory gene, HTLV-1 bZIP factor (HBZ), is continuously expressed and has been implicated in HTLV-1 pathogene...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
John M Coffin

After the discovery of retroviral reverse transcriptase in 1970, there was a flurry of activity, sparked by the "War on Cancer," to identify human cancer retroviruses. After many false claims resulting from various artifacts, most scientists abandoned the search, but the Gallo laboratory carried on, developing both specific assays and new cell culture methods that enabled them to report, in the...

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